ArticleMolecular biology reports2025
Adiponectin 1 receptor is increased but not adiponectin levels in the tumour microenvironment of postmenopausal women with breast cancer.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo analyze the ADIPOQ and ADIPOR1 levels in breast tumour tissue and adjacent adipose tissue of postmenopausal women with this cancer. We hypothesized that the tumour microenvironment (TME) of the breast had lower levels of ADIPOQ and ADIPOR1 in postmenopausal women with obesity than in those with a normal BMI. METHODS AND
resultsTwenty women with normal body mass index (BMI) and 20 with obesity, all of them postmenopausal and with breast cancer (BC) were included. We obtained during surgery fresh breast tumour tissue and a fragment of breast adipose tissue adjacent to the tumour and analyzed the levels of adiponectin (ADIPOQ) and its receptor ADIPOR1 by Western blot. Statistical power of the study was > 80% with a p < 0.05ADIPOR1 protein levels were higher in breast tumour tissue versus breast adipose tissue adjacent to the tumour in postmenopausal women with normal BMI and postmenopausal women with obesity (p = 0.0012 and p = 0.0001, respectively). Moreover, we observed higher ADIPOR1 levels only in breast adipose tissue adjacent to the tumour in postmenopausal women with obesity and tumour size > 2.0 cm and clinical stage II/III (p = 0.019 and p = 0.025, respectively) versus postmenopausal women with a normal BMI. We did not observe differences in ADIPOQ.
conclusionsADIPOR1 levels were higher in breast tumour tissue compared to breast adipose tissue adjacent to the tumour in both postmenopausal women with normal BMI or with obesity. Besides, ADIPOR1 levels were higher in breast adipose tissue adjacent to the tumour of postmenopausal women and obesity, with a more aggressive breast tumour.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.