ReviewLasers in surgery and medicine2026
Monopolar Radiofrequency for Dermal Prejuvenation: Scientific Rationale and Mechanisms of Action.
Review in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Objective and subjective retrospective evaluation of XERF, a novel single-shot dual-frequency non-invasive monopolar radiofrequency.Lasers in medical science · 2026Article
- Comparative study of histological differences according to monopolar radiofrequency tip width.Lasers in medical science · 2026Article
- Monopolar Radiofrequency for Dermal Prejuvenation: Scientific Rationale and Mechanisms of Action.Lasers in surgery and medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo summarize the scientific rationale for the use of the monopolar radiofrequency tissue tightening system (monoRF) for the prevention of dermal aging (termed prejuvenation). MATERIALS AND
methodsThis narrative review summarizes the basic science of dermal aging and monoRF-induced collagen remodeling and neocollagenesis. Studies supporting the mechanism of action of monoRF treatment and its use for prejuvenation are reviewed.
resultsDermal aging is largely attributed to the accumulation of fragmented collagen and depleted collagen levels. Collagen remodeling and neocollagenesis may be induced by monoRF treatment, resulting in immediate tissue tightening and subsequent collagen production, respectively. Preliminary data and expert opinion suggest that early and repeated intervention with monoRF may prevent progressive skin laxity via synergistic and cumulative effects.
conclusionsMonoRF treatment shows potential as a prejuvenation strategy, with preliminary evidence supporting that it induces collagen remodeling and neocollagenesis. Future research should focus on long-term, prospective studies to determine the preventive benefits of consistent annual treatment for aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.