ArticleMicrobiome2025
From maternal microbes to offspring development: gut microbiota-derived thiamine regulates the gut microbiota and drives the placental Notch pathway to coordinate angiogenesis and nutrient transport.
Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Maternal and infant gut microbiome.iMeta · 2026Review
- Microbial-enzymatic co-fermentation of feather meal for bioactive peptide production and its multi-pathway synergistic regulation of intestinal health in broilers.Poultry science · 2026Article
- The Maternal Microbiome in Pregnancy: From Physiological Changes to Dysbiosis and Obstetrical Complications-Therapeutic Perspectives.Life (Basel, Switzerland) · 2026Review
- Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development.Comprehensive Physiology · 2026Review
- The maternal gut-fetal brain axis: role of maternal microbial metabolome in early neurodevelopment.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe maternal gut microbiota can modulate host physiological homeostasis through metabolites. Maternal reproductive potential hinges on placental angiogenesis and nutrient transport efficiency, directly determining fetal developmental outcomes. However, the specific molecular mechanisms by which microbial metabolites influence reproductive potential remain to be elucidated. This study aimed to clarify the mechanisms by which maternal gut microbiota affects reproductive potential.
resultsWe initially analyzed the metabolic profiles by untargeted metabolomics and the fecal microbiota by 16S rRNA sequencing in sows with different reproductive potential. Sows with high reproductive potential exhibited elevated plasma arginine and fecal thiamine levels. Meanwhile, Lactococcus was enriched in the feces of sows with high reproductive potential. Subsequently, we evaluated the effects of thiamine (a signature metabolite identified) on maternal reproductive potential, gut microbiota, placental angiogenesis, and nutrient transport capacity using a rat model. The results showed that thiamine supplementation in pregnant rats effectively promoted offspring growth and enhanced transplacental thiamine metabolism. Moreover, thiamine modulated maternal gut microbiota composition, increased the abundance of Prevotellaceae Ga6A1 group and Bacteroidale RF16 group unclassified, and promoted butyrate production. We found that thiamine improved placental function by enhancing thiamine-related metabolic enzymes and acetyl-CoA content. It also promoted the migratory capacity of pTr cells. Importantly, thiamine facilitated placental angiogenesis by activating Notch signal transduction, which in turn initiated the PI3K/AKT signaling cascade. Ultimately, this cascade regulated the efficiency of placental nutrient metabolism and the expression of nutrient transporters.
conclusionsCumulatively, the gut microbiota regulates early offspring development through metabolite-mediated host interactions. This study provides new evidence that maternal gut microbiota-derived thiamine activates placental Notch signaling to coordinate angiogenesis and nutrient transport, thereby improving pregnancy outcomes. These findings provide novel perspectives and potential actionable strategies for maternal microbial regulation of maternal-fetal health during gestation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.