ArticleBMC chemistry2025
Polymer-metal oxide composites of CuO and NiO as antimicrobial agents.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
To evaluate the antimicrobial potential of polymer-metal oxide composites, the previously developed M8 polymer blend-comprising chitosan, polyethylene glycol, polyvinyl alcohol, and polyvinylpyrrolidone-was modified with copper oxide (CuO) and nickel oxide (NiO) particles, having average sizes of 152.7 ± 4.5 nm and 91.4 ± 4.9 nm, respectively. The resulting composites (M8/CuO and M8/NiO) were tested against Staphylococcus aureus (SA), Pseudomonas aeruginosa (PA), and Salmonella enterica (SE). In previous work, pure M8 exhibited minimum inhibitory concentration (MIC90) values of 12.5% dilution against SA. In the present study, both M8/CuO and M8/NiO displayed MIC50 values of 25% dilution against SE and PA. Against SA, M8/NiO retained higher efficacy (MIC50 = 12.5% dilution) compared with M8/CuO (25% dilution). M8/NiO achieved MIC90 for PA and SE at 25% dilution and 50% dilution, respectively, while M8/CuO reached MIC90 only for SE at 50% dilution. Neither composite attained MIC90 against SA.
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