Evidence map›Paper›PMID 41455877›Full record

ArticleObesity surgery2026

Sex Differences in Body Weight Regulation and Hepatic Insulin Signaling Following Bariatric Surgery and Postoperative Diet in Obese Rats.

Tanja Jevdjovic, Predrag Vujovic, Andjela Milicevic, Iva Lakic, Samir Muhovic, Aida Topic, Amina Valjevac, Tamara Dakic

Abstract read
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Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Tanja JevdjovicDepartment for Animal and Human Physiology, Institute for Physiology and Biochemistry "Ivan Djaja", University of Belgrade, Belgrade, Serbia.
Predrag VujovicDepartment for Animal and Human Physiology, Institute for Physiology and Biochemistry "Ivan Djaja", University of Belgrade, Belgrade, Serbia.
Andjela MilicevicDepartment for Animal and Human Physiology, Institute for Physiology and Biochemistry "Ivan Djaja", University of Belgrade, Belgrade, Serbia.
Iva LakicDepartment for Animal and Human Physiology, Institute for Physiology and Biochemistry "Ivan Djaja", University of Belgrade, Belgrade, Serbia.
Samir MuhovicClinic of General and Abdominal Surgery, Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Aida TopicEar, Nose and Throat Clinic with Head and Neck Surgery, Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Amina ValjevacDepartment of Human Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Tamara DakicDepartment for Animal and Human Physiology, Institute for Physiology and Biochemistry "Ivan Djaja", University of Belgrade, Belgrade, Serbia. tamara.dakic@bio.bg.ac.rs.

Funding

Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-137/2025-03/ 200178
6 · The paper itself

Abstract

introductionThe global obesity prevalence demands new strategies for its treatment. We evaluated sleeve gastrectomy (SG) and biliopancreatic diversion (BD) effects on body weight and hepatic insulin signaling outcomes in high-fat diet (HFD)-induced obese rats, with attention to postoperative diet and sex.

methodsWistar rats received a four-week HFD, then underwent SG or BD. Postoperatively, half of each experimental group remained on HFD and half switched to standard chow for four weeks. Serum glycemia and insulin as well as hepatic GLUT1/GLUT2, IR, p-IR (Tyr1361), Akt, and p-Akt (Ser473) were assessed.

resultsSG and BD produced comparable weight loss. However, a switch to standard chow yielded additional weight loss only in females. Postoperative diet did not alter glycemia, aligning with weight-independent, surgery-driven mechanisms. Serum insulin was unchanged in males but decreased in females after SG/BD, with a further decline on chow. At the hepatic level, IR abundance increased in both sexes, whereas IR activation was surgery/diet-sensitive only in males. Conversely, p-Akt/Akt rose with chow only in females, indicating enhanced hepatic insulin sensitivity without a requisite increase in IR phosphorylation.

conclusionBoth procedures significantly reduced body weight and lowered blood glucose in males and females. Switching to standard chow further enhanced weight loss and insulin sensitivity in females. Hepatic glucose transporter and signaling responses varied by sex, surgery, and postoperative diet. These findings underscore sex-related, independent effects of surgery and postoperative diet and argue for tailored nutritional management after bariatric procedures.

Indexed as

Bariatric SurgeryBiliopancreatic DiversionInsulinLiverObesityAnimalsBlood GlucoseDiet, High-FatDisease Models, AnimalFemaleGastrectomyInsulin ResistanceMalePostoperative PeriodProto-Oncogene Proteins c-aktRatsBlood GlucoseInsulinProto-Oncogene Proteins c-aktBiliopancreatic diversionGLUTsInsulin signalingLiverObesitySleeve gastrectomy

Identifiers

PMID41455877

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