Evidence map›Paper›PMID 41455834›Full record

ArticleScientific reports2025

Structural analysis and antimicrobial assessment of bioinspired silver nanoparticles from Ferula communis.

Yasmeen M G Alshamari, Hamad Z Alkhathlan, Ponmurugan Karuppiah, Mujeeb Khan, Ekram Y Danish, Ahmad Aqel, Syed Farooq Adil, Mohammed Rafi Shaik, Merajuddin Khan

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yasmeen M G AlshamariDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O Box 80200, Jeddah, 21589, Saudi Arabia.
Hamad Z AlkhathlanDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. khathlan@ksu.edu.sa.
Ponmurugan KaruppiahDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Mujeeb KhanDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Ekram Y DanishDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O Box 80200, Jeddah, 21589, Saudi Arabia.
Ahmad AqelDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Syed Farooq AdilDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Mohammed Rafi ShaikDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Merajuddin KhanDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia. mkhan3@ksu.edu.sa.

Funding

Ongoing Research Funding Program, King Saud University, Riyadh, Saudi Arabia ORF-2025-817
6 · The paper itself

Abstract

The green synthesis of nanoparticles using plant extracts has garnered significant interest from scientists worldwide due to its advantages over traditional chemical processes. This method is rapid, eco-friendly, non-toxic, and cost-effective. The current study focuses on preparing silver nanoparticles (AgNPs) using Ferula communis extract as a green reducing agent. During the study, various parameters were evaluated to study their effect on the shape, size, and yield of the AgNPs. The synthesized AgNPs were thoroughly characterized using multiple techniques, confirming the production of crystalline, spherical-shaped NPs, while the plant extract served as the reducing agent. GC-MS analysis was performed to identify the key phytochemicals responsible for reducing silver salts, as well as to characterize the entire phytochemical spectrum present in the F. communis extract. This analysis revealed a total of 67 compounds, with stigmasterol, pentadecanoic acid, (5E, 9Z)-farnesyl acetone, and pentyl decanoates being the most predominant, possibly playing crucial roles in the synthesis of AgNPs. Furthermore, the antimicrobial activity of the AgNPs against various bacterial and fungal strains was investigated. The results showed that Staphylococcus aureus exhibited the largest inhibition zone (10.05 ± 0.05 mm), followed by Escherichia coli (9.25 ± 0.05 mm), Candida albicans (8.70 ± 0.05 mm), Pseudomonas aeruginosa (8.50 ± 0.20 mm), Aspergillus niger (8.45 ± 0.00 mm), Klebsiella pneumoniae (8.15 ± 0.50 mm), and Bacillus subtilis (7.55 ± 0.20 mm). The plant extract was also tested against the same microbial pathogens; however, it only displayed an inhibitory effect against E. coli, with an inhibition zone of 6.50 ± 0.10 mm. These results indicate that the synergistic effect between AgNPs and the residual phytoconstituents on the surface of the NPs plays a significant role in enhancing the antimicrobial properties of the resulting material.

Indexed as

Anti-Infective AgentsFerulaMetal NanoparticlesPlant ExtractsSilverAnti-Bacterial AgentsBacteriaGas Chromatography-Mass SpectrometryGreen Chemistry TechnologyMicrobial Sensitivity TestsPhytochemicalsStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsPhytochemicalsPlant ExtractsSilverAntimicrobial activityBiomedical applicationsFerula communisGreen synthesisSilver nanoparticles

Identifiers

PMID41455834
PMCPMC12835077

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.