Evidence map›Paper›PMID 41455827›Full record

ArticleEye (London, England)2026

Three-year outcomes of polypoidal choroidal vasculopathy according to polypoidal regression on optical coherence tomography angiography.

Jaehwan Choi, Jong Beom Park, Junwoo Lee, Kiyoung Kim, Eung Suk Kim, Seung-Young Yu

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Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jaehwan Choi *Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea.
Jong Beom Park *Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea.
Junwoo LeeDepartment of Ophthalmology, Gachon University Gil Medical Center, Incheon, Korea.
Kiyoung KimDepartment of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea.
Eung Suk KimDepartment of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea.
Seung-Young YuDepartment of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea. syyu@khu.ac.kr.ORCID 0000-0002-3729-5178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the 3-year outcomes of polypoidal choroidal vasculopathy (PCV) according to early polypoidal regression on swept-source optical coherence tomography angiography (SS-OCTA).

methodsThe medical records of 48 polypoidal lesions from 29 eyes of 29 patients diagnosed with PCV with a follow-up ≥3 years were retrospectively reviewed. Patients were divided according to SS-OCTA-defined polypoidal regression 3 months after the initial treatment into the regressed and persistent group. SS-OCTA images were analysed for microvascular and structural changes associated with early complete polypoidal regression.

resultsCompared with the persistent group, the regressed group (20 eyes), had better best-corrected visual acuity (BCVA) at 1 and 3 years (p = 0.000, p = 0.026, respectively) and less patients diagnosed with systemic hypertension (p = 0.043). The number of persistent polypoidal lesions 3 months after the initial treatment was significantly correlated with BCVA at 1 and 3 years (r = 0.498 p = 0.006 and r = 0.397 p = 0.033, respectively). Age, hypertension, number of persistent polypoidal lesions observed 3 months after initial treatment, and the baseline subfoveal choroidal thickness were also associated with the BCVA at 3 years after treatment. Early complete polypoidal regression was associated with a smaller hyperreflective lesion area within pigment epithelial detachment (PED) (p = 0.047, p = 0.024) and more flow signals in hyperreflective lesions (p = 0.047).

conclusionsEyes with early polypoidal regression showed better long-term visual outcomes than those with persistent polypoidal lesions. A smaller hyperreflective lesion area within the PED and more flow signals in the hyperreflective lesions could be considered favourable characteristics for early complete polypoidal regression.

Indexed as

ChoroidChoroidal NeovascularizationFluorescein AngiographyPolypsTomography, Optical CoherenceAgedAged, 80 and overAngiogenesis InhibitorsFemaleFollow-Up StudiesHumansMaleMiddle AgedPolypoidal Choroidal VasculopathyRetrospective StudiesVisual AcuityAngiogenesis Inhibitors

Identifiers

PMID41455827
PMCPMC12957514

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