Trial reportEye (London, England)2026
Drugs with meibomian gland expression alone versus combined with intense pulsed light in ocular rosacea: a randomised controlled study.
Trial report in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Methamphetamine-Driven Neuroinflammation and Parkinson's Disease Pathology: Mechanistic Insight into Nrf2 and NFĸB Signaling.Molecular neurobiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the effects of intense pulsed light (IPL) combined with meibomian gland expression (MGX) and topical medication on ocular rosacea and assess glutathione peroxidases (GPxs) change in the meibum after IPL treatments.
methodsNinety-six eyes of 48 participants with ocular rosacea were randomly assigned to either MGX with erythromycin eye ointment alone (control group) or the combination with IPL (treatment group). During the five visits, participants underwent four IPL or sham IPL sessions at intervals of 2 weeks ± 3 days. The best corrected visual acuity, intraocular pressure, ocular surface disease index (OSDI) questionnaire, lid margin telangiectasia grade, tear break-up time (TBUT), corneal fluorescein staining (CFS), marx line (ML) score, Schirmer's test, meibomian gland yield secretion score (MGYSS), meibography, Demodex were evaluated sequentially. The meibum collected from participants and cryosections of mouse meibomian glands were used for the determination of GPxs or GPx-3.
resultsThe TBUT revealed significant improvement in the treatment group compared to the control group (p < 0.001). The lower lid margin telangiectasia grade (p < 0.001), MGYSS, lower eyelid ML score and CFS exhibited significant improvement in the treatment group compared to the control group. However, the OSDI score, upper lid margin telangiectasia grade, upper eyelid ML score, Schirmer's test, meibography and Demodex showed no statistical difference between the two groups. The GPxs and GPx-3 showed significant increase after IPL treatment.
conclusionsIPL offered additional benefit in stabilising the tear film, improving the secretion of meibomian gland and reducing abnormal eyelid vascularity. GPxs could be a therapeutic target in IPL treatment.
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