Evidence map›Paper›PMID 41455774›Full record

ReviewPediatric nephrology (Berlin, Germany)2026

Gold Standard GFR measurement and GFR estimation in pediatric oncology - indications and limitations.

Emil den Bakker, Martine F Raphael, Arend Bokenkamp

Abstract readReview
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emil den BakkerDepartment of Pediatric Nephrology, Amsterdam University Medical Center, Emma Children's Hospital, Meibergdreef 9, NL-1105 AZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7300-9378
Martine F RaphaelDepartment of Pediatric Oncology, Emma Children's Hospital, Amsterdam, The Netherlands.
Arend BokenkampDepartment of Pediatric Nephrology, Amsterdam University Medical Center, Emma Children's Hospital, Meibergdreef 9, NL-1105 AZ, Amsterdam, The Netherlands. a.bokenkamp@amsterdamumc.nl.ORCID http://orcid.org/0000-0002-3492-2252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knowledge of glomerular filtration rate (GFR) is essential for the treatment and monitoring of children with a malignancy. Ideally, GFR is measured using the gold standard technique of renal inulin clearance. Still, this procedure is too invasive and time-consuming for routine clinical practice. Also, the armamentarium of markers suitable for GFR measurement (mGFR) has changed in the last decades, with iohexol clearance now being used in many countries, both in Europe and the US. For daily monitoring of kidney function, cystatin C has proven to be an important adjunct to serum creatinine, the standard marker of GFR. This review gives a comprehensive update on the indications and limitations of mGFR methods as well as the estimation of GFR from serum markers (eGFR) with special emphasis on children treated for a malignancy.

Indexed as

Glomerular Filtration RateKidneyKidney Function TestsNeoplasmsBiomarkersChildCreatinineCystatin CHumansInulinBiomarkersCreatinineCystatin CInulinCarboplatinChildrenCreatinineCystatin CEstimated GFRMalignancyMeasured GFR

Identifiers

PMID41455774
PMCPMC13424234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.