Evidence map›Paper›PMID 41455772›Full record

SynthesisTechniques in coloproctology2025

Integrating multimodal prehabilitation into enhanced recovery after surgery programs (MPhERAS) for elderly patients: a systematic review and meta-analysis of randomized controlled trials and cohort studies.

A Srinivasan, K M Yi, D Sharma, S K Mantoo

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Techniques in coloproctology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A SrinivasanSingapore General Hospital, Singapore, Singapore. anishsrinivasan98@gmail.com.ORCID 0009-0005-7671-7221
K M YiSingapore General Hospital, Singapore, Singapore.ORCID 0000-0003-0144-4255
D SharmaNSCB Government Medical College Jabalpur, Jabalpur, Madhya Pradesh, India.ORCID 0000-0002-0604-8676
S K MantooNanyang Technological University, Singapore, Singapore.ORCID 0000-0002-7815-0653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery (ERAS) protocols and multimodal prehabilitation are interventions used to improve outcomes after surgery. However, their integration is not well studied and is a subject of ongoing debate. The aim of the study was to evaluate the effectiveness of multimodal prehabilitation within ERAS for elderly patients undergoing elective colorectal surgery.

methodsStudies that used prehabilitation modalities, such as exercise, nutrition, psychology, and spirituality, compared with two control groups-ERAS alone or ERAS with postoperative rehabilitation-were systematically reviewed and reported according to the PRISMA guidelines. Meta-analysis was performed on outcomes such as length of stay (LOS), 6-min walk test (6MWT), postoperative complications, and quality of Life (QOL) using a random effects model.

resultsSix studies with low risk of bias and good quality were selected. These included 547 patients with an age range of 65-78 years in the intervention group (n = 277) and of 66-82 years in the control group (n = 270). All studies exclusively included patients with colorectal cancer. Statistically significant difference was observed for 6MWT and MD of 18.3800 m (95% CI 1.5147-35.2453; p = 0.0404) with an I

conclusionAlthough multimodal prehabilitation in ERAS for elderly patients undergoing elective colorectal surgery has limited clinical use, potential remains for targeted and optimized interventions. Further research is needed to consolidate evidence in selected patient populations.

Indexed as

Enhanced Recovery After SurgeryPreoperative CarePreoperative ExerciseAgedAged, 80 and overCohort StudiesCombined Modality TherapyElective Surgical ProceduresFemaleHumansLength of StayMalePostoperative ComplicationsQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeColorectal surgeryElderlyERASPrehabilitation

Identifiers

PMID41455772
PMCPMC12855354

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.