Evidence map›Paper›PMID 41455532›Full record

ArticleJournal of affective disorders2026

What predicts suicidality among people who self-injure? Evidence for acquired capability via pain habituation and NSSI severity.

Johanna Hepp, Sophia Rose, Timothy J Trull, Ryan W Carpenter

Abstract read
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Frontiers in psychiatry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Johanna HeppDepartment of Psychosomatic Medicine, Central Institute of Mental Health, Medical Faculty Mannheim at Heidelberg University, Mannheim, Germany. Electronic address: Johanna.hepp@zi-mannheim.de.
Sophia RoseDepartment of Psychosomatic Medicine, Central Institute of Mental Health, Medical Faculty Mannheim at Heidelberg University, Mannheim, Germany.
Timothy J TrullDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Ryan W CarpenterDepartment of Psychology, University of Notre Dame, Notre Dame, USA.

Funding

Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatmentK23AA029729 · NIAAA · UNIVERSITY OF NOTRE DAME · PI Ryan W Carpenter · 2022 to 2026
$793k
NIAAA NIH HHS K23 AA029729
6 · The paper itself

Abstract

Individuals who engage in non-suicidal self-injury (NSSI) are at heightened risk for suicide. However, not all individuals who self-injure are equally vulnerable, and it remains unclear which specific NSSI characteristics confer greater risk for suicidal behavior and suicide attempts. This study examined a large online sample (N = 1227) of individuals who had engaged in NSSI within the past six months, assessing associations between suicidal outcomes and NSSI-related variables, including frequency, number of methods used, injury severity, need for medical attention, pain experienced during NSSI, and perceived changes in pain over time. Participants completed self-report measures of suicidal behavior (using the Suicide Behaviors Questionnaire-Revised, SBQ-R), lifetime suicide attempts, and a battery of items characterizing their NSSI behavior. Multiple regression analyses were used to predict SBQ-R scores, and negative binomial regressions were conducted for the count outcome of past suicide attempts, adjusting for gender and age. Results indicated that higher NSSI frequency, use of a greater number of methods, greater self-reported severity and need for medical attention, as well as reductions in pain over time were all significantly associated with greater suicidal behavior and more suicide attempts. These findings align with the interpersonal theory of suicide, which posits that habituation to painful stimuli can contribute to an increased acquired capability for suicide. The results underscore the importance of evaluating specific NSSI characteristics during suicide risk assessments in clinical settings and highlight changes in NSSI associated pain and past need for medical attention as possible targets of future research.

Indexed as

Habituation, PsychophysiologicPainSelf-Injurious BehaviorSuicidal IdeationSuicide, AttemptedAdolescentAdultFemaleHumansMaleMiddle AgedRisk FactorsSelf ReportSeverity of Illness IndexSurveys and QuestionnairesYoung AdultAcquired capabilityInterpersonal theory of suicideNon-suicidal self-injuryNSSIPainSuicide

Identifiers

PMID41455532
PMCPMC12917755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.