Evidence map›Paper›PMID 41455468›Full record

ArticleStem cell reports2026

Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs.

Wuyang Tang, Linlin Zhang, Pu Cao, Shengjun Bai, Meilin Sun, Jialun Li, Yuhang Zhang, Yan Wang, Di Tu, Jiemin Wong and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wuyang TangCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China.
Linlin ZhangCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China.
Pu CaoCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China.
Shengjun BaiKey Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Meilin SunShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Jialun LiShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yuhang ZhangCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China.
Yan WangCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China.
Di TuCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China.
Jiemin WongShanghai Key Laboratory of Regulatory Biology, Fengxian District Central Hospital-ECNU Joint Center of Translational Medicine, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
Yufeng QinKey Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Brian D BennettIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Guang HuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: hug4@niehs.nih.gov.
Xiaofeng ZhengCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China. Electronic address: zheng.x@hunau.edu.cn.
Pishun LiCollege of Veterinary Medicine and Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China; Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: lipishun@hunau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryonic stem cells (ESCs) can self-renew and differentiate into somatic cells. They can also adopt a totipotent-like state and become 2-cell-like cells (2CLCs). However, how these progresses are regulated remains poorly understood. Here, we define a novel role for Rbm25 (RNA-binding motif protein 25), previously known as a splicing regulator, in the maintenance of ESC identity. Rbm25 is highly expressed in ESCs and is downregulated during differentiation. Deletion or depletion of Rbm25 impairs ESC self-renewal and differentiation and promotes the transition toward 2CLCs. Mechanistically, RBM25 occupies pluripotency- and DNA methylation-related gene promoters and directly regulates their expression, thereby governing the gene expression program and the epigenetic state of ESCs. Together, our data indicate that Rbm25 controls stem cell fate specification at the transcription level and therefore uncover a new role of Rbm25 as a transcriptional regulator.

Indexed as

Embryonic Stem CellsEpigenesis, GeneticMouse Embryonic Stem CellsPluripotent Stem CellsRNA-Binding ProteinsTranscription, GeneticAnimalsCell DifferentiationCell LineageCell Self RenewalDNA MethylationGene Expression Regulation, DevelopmentalMicePromoter Regions, GeneticRNA-Binding Proteins2-cell-like cellsembryonic stem cellsepigeneticRbm25transcription

Identifiers

PMID41455468
PMCPMC12925954

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.