Evidence map›Paper›PMID 41455463›Full record

ArticleJournal of the neurological sciences2026

Effects of surgical therapies on cognitive function in patients with essential tremor.

Vibhash D Sharma, Diane S Berry, Stephanie Cosentino, Elan D Louis

Abstract read
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Article in Journal of the neurological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vibhash D SharmaDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: vibhash.sharma@UTSouthwestern.edu.
Diane S BerryDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Stephanie CosentinoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY, USA; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Elan D LouisDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

Clinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1M
NINDS NIH HHS R01 NS086736
6 · The paper itself

Abstract

backgroundEssential tremor (ET) is associated with increased risk of cognitive decline, particularly with advancing age. Surgical therapies, such as deep brain stimulation (DBS) and MR-guided focused ultrasound (MRgFUS), are effective treatment options for tremor, but their long-term cognitive effects remain unclear. This is the first study to compare ET patients who underwent surgery to those who had not.

objectiveWe assessed cognitive outcomes in ET patients who underwent surgical therapies and compared them to non-surgical controls.

methodsWe identified both surgical (n = 12) and non-surgical ET cases (n = 188) from a large prospective longitudinal study and compared their cognitive function. Cognitive function was assessed prior to and following surgery, over the course of 36- and 54-month intervals. Mixed model analyses of covariance were used to assess cognitive changes over time, controlling for age, global cognitive scores, years of education, and study visit.

resultsAlthough both groups showed modest cognitive decline over time, few significant differences were observed between the surgical and non-surgical groups. Significant group × time interactions were observed for several tests, with the surgical group demonstrating greater decline in some subdomains of Memory and Executive Function.

conclusionSurgical therapies such as DBS and MRgFUS do not appear to broadly impact global cognitive function in older ET patients. However, specific cognitive domains may be more susceptible to decline.

Indexed as

CognitionCognitive DysfunctionDeep Brain StimulationEssential TremorAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsProspective StudiesTreatment OutcomeClinicalCognitionCognitive functionDeep brain stimulationEssential tremorFocused ultrasound

Identifiers

PMID41455463
PMCPMC13477242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.