Evidence map›Paper›PMID 41455091›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Bridging gaps in oncofertility: evaluation of reproductive dysfunction and fertility assessment in pediatric cancer survivors.

Sanjana Sarangarajan, Shivani Deep Singh, Amitabh Singh, Kritika Setlur, Spondita Banerjee, Neeta Singh, Neena Malhotra, Aditya Kumar Gupta, Jagdish Prasad Meena, Rachna Seth

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sanjana SarangarajanDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India.
Shivani Deep SinghDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India.
Amitabh SinghDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India.
Kritika SetlurDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India.
Spondita BanerjeeDepartment of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Neeta SinghDepartment of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Neena MalhotraDepartment of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Aditya Kumar GuptaDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India.
Jagdish Prasad MeenaDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India.
Rachna SethDivision of Pediatric Oncology, Department of Pediatrics, Mother & Child Block, All India Institute of Medical Sciences, New Delhi, 110029, India. drrachnaseth1967@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith improved survival in pediatric cancers, late effects such as reproductive dysfunction and infertility have emerged as a major concern. Oncofertility services remain underdeveloped in India, particularly in public sector institutions. We aimed to evaluate reproductive function and fertility preservation practices in childhood cancer survivors (CCS) attending a tertiary care center in India.

methodThis was a cross-sectional study of CCS enrolled at the Pediatric Cancer Survivor Clinic of AIIMS, New Delhi, between January 2022 and December 2024. Survivors ≥ 8 years of age with prior gonadotoxic therapy were included. Hormonal assays, semen analysis, and ovarian reserve evaluations were conducted. Interventions were offered based as indicated. FINDING: The cohort included 87 males and 45 females, mostly treated for hemato-lymphoid malignancies. Hypogonadism was identified in 76.3% of males based on low testosterone, and azoospermia in 50% of those tested. Among females, 56.8% of those tested had low anti-Müllerian hormone (AMH) levels, and 62.5% of those tested had reduced antral follicle count. Despite high-risk features, fertility preservation uptake was poor. Only five females received hormone replacement therapy. Cultural barriers and financial constraints were major deterrents.

conclusionThere is a high burden of reproductive dysfunction among Indian CCS, with significant gaps in fertility preservation. Early integration of oncofertility services within oncology care is feasible and essential. Structured, multidisciplinary models and non-governmental organization (NGO) support can help bridge current gaps in LMICs.

Indexed as

Cancer SurvivorsFertility PreservationInfertilityNeoplasmsAdolescentAdultChildCross-Sectional StudiesFemaleHumansIndiaMaleOvarian ReserveSemen AnalysisYoung AdultChildhood cancer survivorsFertilityReproductive dysfunction

Identifiers

PMID41455091

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