ArticleMycotoxin research2025
Aflatoxin B1 interferes with lncRNA-mRNA network to inhibit proliferation of bovine endometrial epithelial cells.
Article in Mycotoxin research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
Aflatoxin B1 (AFB1), a common feed contaminant, causes substantial economic losses in animal husbandry and threatens reproductive health. This study investigated the toxic mechanisms of AFB1 on bovine endometrial epithelial cells using in vitro experiments. Treatment with 5 μg/mL AFB1 for 24 h significantly inhibited cell proliferation and induced apoptosis, indicated by a reduced EdU-positive rate and increased Bax/Bcl-2 ratio and Caspase-3 expression. Transcriptome sequencing identified 810 differentially expressed mRNAs and 88 upregulated lncRNAs, which were primarily enriched in calcium signaling, oxytocin, and GnRH pathways. Experimental validation confirmed that AFB1 elevated intracellular Ca
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