Evidence map›Paper›PMID 41455043›Full record

ArticleDiscover oncology2025

The impact of tumor-associated inflammatory adhesions on survival and treatment strategies in patients with colon cancer.

Jinzhu Zhang, Jichuan Quan, Shucheng Liu, Zhixun Zhao, Hengchang Liu, Jianqiang Tang, Haipeng Chen, Xishan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jinzhu Zhang *Department of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China.
Jichuan Quan *Department of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China.
Shucheng Liu *Department of Anorectal Surgery, Chifeng Municipal Hospital, Chifeng, China.
Zhixun ZhaoDepartment of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China.
Hengchang LiuDepartment of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China.
Jianqiang Tang *Department of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China. doc_tjq@hotmail.com.
Haipeng Chen *Department of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China. 214787653@qq.com.
Xishan Wang *Department of Colorectal Surgery, National Clinical Research Center for Cancer/Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 17 Panjiayuan South Lane, Chaoyang District, Beijing, 100021, China. wxshan_1208@126.com.

Funding

Beijing Chaoyang District Science and Technology Program D13221the National Natural Science Foundation of China 82072732
6 · The paper itself

Abstract

purposeIn colon cancer patients with tumor-associated inflammatory adhesions (TAIA), the preoperative clinical staging is cT4b, but postoperative pathology reveals that the tumor has not invaded surrounding organs (non-pT4b). We aimed to investigate the impact of TAIA on prognosis and treatment strategies for colon cancer patients.

methodsColon cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database (2010 to 2019) and Chinese multicenter cohort were included to compare survival differences between the TAIA and non-TAIA groups. A Cox proportional hazards model was used to evaluate independent risk factors for survival in colon cancer patients. Additionally, we analyzed the impact of adjuvant chemotherapy on survival in TAIA patients.

resultsA total of 112,659 colon cancer patients from the SEER database and 881 colon cancer patients from the Chinese database were included in this study. After PSM, both cohorts found that patients in the TAIA group exhibited worse overall survival (P < 0.05) and cancer-specific survival (P < 0.05). Additionally, the Cox multivariate proportional hazards model identified TAIA as an independent risk factor for cancer-specific survival in colon cancer patients (SEER: HR 1.45, 95% CI: 1.40-1.50, P < 0.001; China: HR 2.108, 95% CI: 1.473-3.015, P < 0.001). Subsequently, 36,496 TAIA patients from the SEER database and 229 TAIA patients from a Chinese multicenter database were independently divided into adjuvant chemotherapy and control groups. After PSM, both databases indicated better survival in the adjuvant chemotherapy group.

conclusionColon cancer patients with TAIA have a poorer prognosis. Adjuvant chemotherapy can improve the prognosis of TAIA patients.

Indexed as

Adjuvant chemotherapyColon cancerPrognosisTumor-associated inflammatory adhesions

Identifiers

PMID41455043
PMCPMC12852523

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