ArticleCancer causes & control : CCC2025
Demographic disparities in temporal trends and geographic variations of malignant pleural and peritoneal mesothelioma incidence in Pennsylvania, 1990-2019.
Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeMalignant mesothelioma is a rare but aggressive cancer primarily linked to asbestos exposure. While pleural mesothelioma has been extensively studied, peritoneal mesothelioma remains less understood, especially regarding demographic disparities and geographic variation. This study examined demographic differences in trends and geographic variation in pleural and peritoneal mesothelioma incidence in Pennsylvania over a 30-year period.
methodsThis population-based study analyzed mesothelioma incidence reported to the Pennsylvania Cancer Registry from 1990 to 2019. Trends were assessed by calculating age-adjusted and age-specific incidence rates and corresponding annual percent changes by sex, race and ethnicity, and age group. County-level standardized incidence ratios (SIRs) were mapped to illustrate the spatial distributions of pleural and peritoneal mesothelioma.
resultsPleural mesothelioma incidence rates were significantly higher among men, White people, and people aged ≥ 60 years. Overall, pleural mesothelioma incidence increased until the early 2000s and declined thereafter. In contrast, peritoneal mesothelioma incidence remained low and stable, except for a significantly increasing trend observed among women and people aged < 60 years. The geographic distributions of peritoneal and pleural mesothelioma incidence across Pennsylvania counties showed overlapping areas of elevated SIRs in the southeastern, western, and north-central regions.
conclusionThis study highlights distinct trends in pleural and peritoneal mesothelioma incidence, along with associated demographic disparities and geographic variation. These findings suggest that pleural mesothelioma incidence likely reflects historical occupational asbestos exposure, whereas peritoneal mesothelioma appears less strongly associated. Further research is warranted to clarify the associations between various sources of asbestos exposure and pleural and peritoneal mesothelioma risk.
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