ArticleEuropean archives of psychiatry and clinical neuroscience2026
Association between specific neuroticism symptoms and cardiovascular disease: insights from genetic analysis.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The interplay between mental health, ecological factors, and problematic smartphone use: a network analysis in adolescents with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- The architecture of depression and comorbid symptoms in chinese vocational college students: a dual-method network analysis.Social psychiatry and psychiatric epidemiology · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
Although neuroticism has been linked to cardiovascular disease (CVD), the etiological relevance of individual neuroticism symptoms remains poorly understood. In this study, we employed Linkage disequilibrium score regression (LDSC) and systematic Mendelian randomization (MR) analyses to examine the potential causal effects of specific neuroticism symptoms on CVD. We obtained summary-level data on 13 specific neuroticism symptoms from the UK Biobank (ranging from 366,726-380,506 participants). Summary statistics for CVD originated from three European-descent GWASs with a total of 799,534 participants. LDSC was performed to investigate the genetic associations between specific neuroticism symptoms and CVD. The inversevariance weighted approach was applied to test the causality for the studied associations, together with extensive validation and sensitivity analyses to verify the main results. LDSC revealed significant genetic correlations between most neuroticism symptoms and CVD ri(r
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