ArticlePediatric surgery international2025
Characteristics of children born to mothers with an anorectal malformation.
Article in Pediatric surgery international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo describe characteristics of offspring born to mothers having an anorectal malformation (ARM).
methodsThis was a national population-based cohort study. The exposed group was the offspring of females with an ARM diagnosis (ICD-codes) in the Swedish National Patient Register 1964-2008. The unexposed group was the offspring of mothers without ARM. Five age-matched mothers without ARM were randomly identified for each mother with ARM by Statistics Sweden. Females with chromosomal aberrations were excluded prior to analysis. Outcomes of the mothers were retrieved from the National Patient Register (1964-2021) and Medical Birth Register (1973-2021). Outcomes of the offspring were based on data from Medical Birth Register. Using descriptive statistics, the children of mothers with an ARM were compared to children of mothers not having an ARM. The ethical review authorities approved the study.
resultsThe mothers included 464 females with ARM and 2313 females without ARM. Of the 464 females with ARM, 132 (28.4%) gave birth to at least one child compared with 895 (38.7%) females without ARM (p < 0.001). The 132 first-born children of mothers with ARM were born at an 8-day younger median gestational age (272 days) when compared to children to mothers without ARM (280 days) (p < 0.001). The infants to mothers with ARM were more commonly small for gestational age (n = 10, 7.6%) than infants to mothers without ARM (n = 28, 3.1%) (p = 0.012). Initial results also showed that the first offspring to ARM mothers were statistically lighter and shorter than the offspring to mothers without ARM (p < 0.001), however, after adjusting for gestational age in a linear regression model, this was no longer the case (p = 0.398 and p = 0.255, respectively). Three first-born offspring in the group of mothers with an ARM, whereas no offspring from mothers without ARM had an ARM.
conclusionThe first-born child of mothers with ARM are more commonly small for gestational age than the first-born of mothers without ARM. The offspring to mothers with ARM more commonly had an ARM. LEVEL OF EVIDENCE III:
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