ArticleNeuroradiology2026
Leveraging vision transformer for histological grade prediction in laryngeal and hypopharyngeal squamous cell carcinoma: a large-scale multicenter study.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPretreatment determination of histological differentiation grade is critical for prognostic evaluation in laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC). This study aimed to develop a contrast-enhanced CT (CECT)-based Vision Transformer (ViT) model for noninvasive evaluation of histological grades in LHSCC.
methodsIn this retrospective multicenter study, a total of 1,648 LHSCC patients who underwent CECT scans were enrolled from three hospitals in this study. Participants were divided into a training cohort (n = 1,239), an internal validation cohort (n = 310) from one hospital, and an external validation cohort (n = 99) from the other two hospitals. The diagnostic model integrates a pre-trained ViT for CECT feature extraction and an XGBoost classifier for prediction. The model's predictive performance was evaluated using the area under the curve (AUC), decision curve analysis (DCA), and calibration curve.
resultsThe ViT model achieved AUCs of 0.887 (95%CI: 0.848-0.927) in internal validation and 0.796 (95%CI: 0.693-0.899) in external validation cohorts, significantly outperforming the conventional radiomics model (AUCs: 0.775, 95%CI: 0.714-0.837 and 0.544, 95%CI: 0.388-0.699; p < 0.001 and 0.002, respectively). Clinically, DCA demonstrated superior clinical utility, while calibration curves showed excellent prediction reliability. Gradient-weighted Class Activation Mapping visualization identified CT image regions most influential for the model's predictions, providing interpretability for clinical decision-making.
conclusionThe ViT-based deep learning model developed in this study using CECT demonstrated excellent predictive performance for histological grading of LHSCC, with promising application for patient prognosis assessment.
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