Evidence map›Paper›PMID 41454868›Full record

ArticleJournal of the American Chemical Society2026

The Role of Intrinsically Disordered Domains in Regulating G Protein-Coupled Receptor Signaling.

Jun Xu, Ruoyi Qiu, Alexander M Garces, Harald Hübner, Xinyu Xu, Chengyu Hao, Dorothee Weikert, Peter Gmeiner, Michael T Lerch, Brian K Kobilka

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jun XuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, United States.ORCID 0000-0002-1600-583X
Ruoyi QiuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, United States.
Alexander M GarcesDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Harald HübnerDepartment of Chemistry and Pharmacy Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91058, Germany.ORCID 0000-0002-7892-599X
Xinyu XuDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States.
Chengyu HaoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, United States.
Dorothee WeikertDepartment of Chemistry and Pharmacy Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91058, Germany.ORCID 0000-0003-2259-9002
Peter GmeinerDepartment of Chemistry and Pharmacy Medicinal Chemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91058, Germany.ORCID 0000-0002-4127-197X
Michael T LerchDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, United States.ORCID 0000-0001-5958-3990

Funding

G protein coupled receptor structure, dynamics, and signaling.R35NS137408 · NINDS · STANFORD UNIVERSITY · PI Brian K Kobilka · 2024 to 2026
$1.9M
NINDS NIH HHS R35 NS137408
6 · The paper itself

Abstract

The α

Indexed as

Intrinsically Disordered ProteinsReceptors, Adrenergic, alpha-2Signal TransductionFluorescence Resonance Energy TransferHumansProtein DomainsIntrinsically Disordered ProteinsReceptors, Adrenergic, alpha-2

Identifiers

PMID41454868
PMCPMC13050509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.