Evidence map›Paper›PMID 41454770›Full record

ArticlePathologica2025

Expanding the spectrum of

Damiano Arciuolo, Rita Alaggio, Antonio Travaglino, Giulia Scaglione, Angela Santoro, Isabella Giovannoni, Sabina Barresi, Sara Patrizi, Evelina Miele, Luigi Pedone Anchora and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Damiano ArciuoloCatholic University of Sacred Heart, Rome, Italy.
Rita AlaggioPathology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Antonio TravaglinoUnit of Pathology, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
Giulia ScaglioneGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Angela SantoroGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Isabella GiovannoniPathology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Sabina BarresiPathology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Sara PatriziHematology/Oncology, and Stem Cell Transplantation, Bambino Gesut̀ Children's Hospital, IRCCS, Rome, Italy.
Evelina MieleHematology/Oncology, and Stem Cell Transplantation, Bambino Gesut̀ Children's Hospital, IRCCS, Rome, Italy.
Luigi Pedone AnchoraGynecologic Oncology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Frediano InzaniAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia.
Gian Franco ZannoniGynecopathology and Breast Pathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The AFF2 gene encodes a protein involved in transcriptional regulation and chromatin remodeling. While primarily associated with Fragile X syndrome, AFF2 fusions have recently been identified in certain malignancies, mostly sinonasal squamous cell carcinoma. Recently it has been implicated in an intra-abdominal sarcoma linked to endometriosis. We present the case of a 71-year-old woman with a 19 cm ovarian mass arising in cystic endometriosis. Histological examination revealed high-grade undifferentiated sarcoma with spindle to epithelioid morphology, high nuclear atypia, a high mitotic index, and extensive necrosis. Immunohistochemistry demonstrated positivity for Vimentin, ER, PR, CD10, focal WT1, Desmin, and NTRK, with aberrant In conclusion, this case expands the morphological spectrum of

Indexed as

AcyltransferasesOvarian NeoplasmsSarcomaAgedBiomarkers, TumorFatal OutcomeFemaleGene FusionHumansOncogene Proteins, FusionPrognosisAcyltransferasesBiomarkers, TumorOncogene Proteins, Fusioncystic endometriosisSarcomaundifferentiated gynecologic sarcomaZDHHC9::AFF2 sarcoma

Identifiers

PMID41454770
PMCPMC12743362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.