Evidence map›Paper›PMID 41454765›Full record

ArticlePathologica2025

AI-assisted sentinel lymph node examination and metastatic detection in breast cancer: the potential of ChatGPT for digital pathology research.

Giuseppe Angelico, Saveria Spadola, Angela Santoro, Antonino Mulè, Federica D'Aquila, Gabriele La Cava, Stefano Marletta, Michele Valente, Belen Padial Urtueta, Francesca Addante and 5 more

Abstract read
In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giuseppe AngelicoDepartment of Medicine and Surgery, Kore University of Enna, Enna, Italy.
Saveria SpadolaDepartment of Medicine and Surgery, Kore University of Enna, Enna, Italy.
Angela SantoroPathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Antonino MulèPathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Federica D'AquilaDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, Catania, Italy.
Gabriele La CavaDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, Catania, Italy.
Stefano MarlettaDivision of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy.
Michele ValentePathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Belen Padial UrtuetaPathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Francesca AddantePathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Nadine NarducciPathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Lorenzo MemeoPathology Unit, Department of Experimental Oncology, Mediterranean Institute of Oncology, Catania, Italy.
Cristina ColarossiPathology Unit, Department of Experimental Oncology, Mediterranean Institute of Oncology, Catania, Italy.
Antonio RizzoDivision of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy.
Gian Franco ZannoniPathology Unit, Department of Woman and Child's Health and Public Health Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Traditional pathological examination of lymph nodes is labor-intensive and has shown variability in diagnostic accuracy. Recent advancements in artificial intelligence (AI) provide promising opportunities to enhance and standardize pathological workflows. AI-based image analysis models, particularly those utilizing deep learning algorithms, have demonstrated potential in automating and improving diagnostic accuracy in histopathology. This study aimed to evaluate the performance of a novel AI model known as ChatGPT-4 in detecting metastatic involvement in sentinel lymph nodes (SLNs) from breast cancer cases. Methods: We utilized digital slides from frozen sections, which are commonly employed intraoperatively, to assess the model's diagnostic accuracy. A total of 90 SLNs were retrospectively collected and analyzed using ChatGPT-4. The generated diagnoses were evaluated by two senior pathologists. Results: The AI model achieved an overall accuracy of 92.2%, with a sensitivity of 100% and specificity of 80.6%. The study highlights the practical applicability of AI in diagnosing SLN metastasis, emphasizing the importance of frozen sections in real-world scenarios. Conclusions: These findings suggest that integrating AI models like ChatGPT-4 into pathological workflows could enhance diagnostic accuracy and efficiency in breast cancer treatment.

Indexed as

Artificial IntelligenceBreast NeoplasmsLymphatic MetastasisSentinel Lymph NodeSentinel Lymph Node BiopsyAdultAgedFemaleFrozen SectionsGenerative Artificial IntelligenceHumansMiddle AgedRetrospective StudiesSensitivity and Specificityartificial intelligencebreast cancerChatGPTfrozen sectionssentinel lymph node

Identifiers

PMID41454765
PMCPMC12743367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.