ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Iron/Cobalt Dual-Atom Catalyst Orchestrate Photothermal-Chemodynamic Immunotherapy Against MRSA: Multi-Omics Dissection in Murine and Porcine Models.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Extracellular Vesicle-embedded alginate hydrogel patch for accelerated wound healing.Materials today. Bio · 2026Article
- Aptamer-guided upconversion nanoconstructs enable proximity-dependent and precise photodynamic therapy for MRSA-infected wounds.Materials today. Bio · 2026Article
- A photocuring double-network hydrogel enhances mechanotransduction and scavenges ROS to accelerate pressure injury healing.Materials today. Bio · 2026Article
- NIR-II-triggered copper single-atom catalyst depots coupling catalysis and drug release for infected chronic wounds with dysregulated inflammation.Materials today. Bio · 2026Article
- The enhanced photothermal therapy against gastric cancer by mitochondria/STAT3-targeted nanoplatform with OXPHOS blocking.Materials today. Bio · 2026Article
- Harnessing NIR-II-responsive Rh single-atom nanozymes for photothermal-catalytic immunomodulation and eradication of drug-resistant biofilms in deep tissues.Materials today. Bio · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Translating pathogen-specific molecular insights into effective treatments remains a significant challenge, particularly for drug-resistant wound infections. In this study, we develop a nitrogen-doped iron/cobalt dual-atom catalyst (FeCo-N-DAC) with high metal loading (Fe > 5.4%, Co > 4.8%) as a multifunctional platform that integrates nanozyme-mimicking catalytic activity and photothermal therapy. FeCo-N-DAC mimics multiple natural enzymes to generate reactive oxygen species, disrupt bacterial biofilms, and eradicate methicillin-resistant Staphylococcus aureus (MRSA) in both murine and porcine models of subcutaneous abscesses and infectious wounds, respectively. Upon near-infrared (NIR-II) irradiation, the material exhibits deep-seated tissue penetration and synergistic catalytic-photothermal effects, enabling complete biofilm clearance in otherwise recalcitrant infections. Multi-omics analyses, including transcriptomics and proteomics, reveal that FeCo-N-DAC modulates immune responses and promotes tissue regeneration by reprogramming inflammation- and fibrosis-related pathways. This study highlights the therapeutic potential of dual-atom nanozymes for precision anti-infective therapy and underscores their translational relevance in treating complex, biofilm-associated infections.
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Registered trials
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