ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026
Periventricular gradients in axonal and myelin microstructure are present in people with multiple sclerosis having low and high disability.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMS imaging studies have demonstrated an ependymal "surface-in" distribution of white matter damage. The origin of this effect and how it impacts myelinated axons in people with MS (PwMS) is poorly understood.
objectivesTo investigate (1) whether there is clear evidence of tract-wise, periventricular damage, based on fractional anisotropy, mean diffusivity, axonal water fraction (AWF) and myelin volume fraction (MVF), in PwMS, (2) if such tissue damage is associated with T
methodsWe applied structural, MT-weighted, and multi-shell diffusion MRI in healthy controls and PwMS to quantify periventricular gradient damage to axons and myelin. We also evaluated the correlation between such gradient damage and both non-BH and T
resultsClear periventricular gradients exist in both AWF and MVF measures in the Association and Projection Tracts. They are strongly correlated with T
conclusionsTract-specific, periventricular gradients in PwMS exist prominently in AWF and MVF, are strongly associated with T
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