ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026
Allergic phenotypes and asthma in multiple sclerosis: Epidemiologic and genetic relationships.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMultiple sclerosis (MS) and allergic disorders (ADs) are classically seen as immunologically distinct, and prior studies suggest potential inverse associations and overlapping genetic contributors.
objectivesCompare the prevalence of asthma, and dietary and environmental allergic phenotypes in persons with MS (PwMS) versus unaffected controls, compare AD prevalence by MS clinical course, and evaluate associations between MS genetic risk,
methodsWe analyzed survey and genotype data from 1542 PwMS and 700 controls from the Accelerated Cure Project. Logistic regression models were adjusted for key confounders. Genetic analyses included 1252 unrelated non-Hispanic White PwMS, assessing the main effects of
resultsPwMS had lower odds of seasonal allergies compared to controls (OR = 0.79; 95% CI: 0.65, 0.96), with a non-significant reduction in primary progressive versus relapsing at onset MS (OR = 0.58; 95% CI: 0.37, 0.92). Among PwMS,
conclusionsMS is associated with reduced seasonal allergies. MS genetic risk factors appear to shape allergy susceptibility in PwMS.
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