Evidence map›Paper›PMID 41454664›Full record

ArticleGut microbes2026

Targeting the microbiome in pediatric migraine: gastrointestinal manifestations and the therapeutic role of

Pi-Chuan Fan, Huey-Huey Chua, Chia-Ray Lin, Tzu-Hsuan Lai, Lih-Chu Chiou, Wang-Tso Lee, Huey-Ling Chen, Yen-Hsuan Ni

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In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pi-Chuan FanDivision of Neurology, Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Huey-Huey ChuaDivision of Gastroenterology, Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Ray LinDivision of Gastroenterology, Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Tzu-Hsuan LaiDivision of Neurology, Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Lih-Chu ChiouDepartment and Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taiwan.
Wang-Tso LeeDivision of Neurology, Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Huey-Ling ChenDepartments of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-4074-5838
Yen-Hsuan NiDepartments of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is a disabling neurological disorder that often begins in childhood or adolescence and is frequently accompanied by gastrointestinal (GI) symptoms. However, the microbiota signatures and gut-brain interactions underlying pediatric migraine, particularly in the presence of GI disorder, remain poorly defined. This study aimed to explore the clinical and microbial features of pediatric migraine, as well as the therapeutic potential of probiotics.We prospectively enrolled 126 pediatric migraine patients (ages 6-19) with or without GI disorder and 50 age-matched healthy controls. Fecal microbiota was profiled using 16S rRNA sequencing. Patients with migraine were stratified based on Rome IV-defined GI disorders and evaluated for headache characteristics, PedMIDAS scores (disability assessment), plasma calcitonin gene related peptide (CGRP, thought as a key biomarker of migraine), cytokines, and fecal calprotectin. Probiotic effects were tested in both young (3-4 weeks) and adult capsaicin-induced migraine rat models, and an exploratory pilot study involving 23 pediatric migraine patients.Compared to controls, migraine patients exhibited distinct gut microbiota with reduced

Indexed as

Bifidobacterium longumGastrointestinal DiseasesGastrointestinal MicrobiomeMigraine DisordersProbioticsAdolescentAnimalsCalcitonin Gene-Related PeptideChildFecesFemaleHumansMalePilot ProjectsProspective StudiesRatsCalcitonin Gene-Related PeptideFaecalibacterium prausnitziigastrointestinal disordergut–brain axisGut microbiotapediatric migraineStreptococcus gallolyticus

Identifiers

PMID41454664
PMCPMC12758293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.