Evidence map›Paper›PMID 41454653›Full record

Trial reportNeurorehabilitation and neural repair2026

Higher Intensity Walking Training in Individuals With Chronic Motor Incomplete Spinal Cord Injury: A Randomized Clinical Trial.

T George Hornby, Abbey Plawecki, Jennifer Lotter, Lindsay Shoger, Christina Voigtmann, Lindsay Heffron, Emily Lucas, Devan Parrott, Christopher E Henderson

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

T George HornbyDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-3147-3818
Abbey PlaweckiDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.
Jennifer LotterRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Lindsay ShogerRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Christina VoigtmannRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Lindsay HeffronRehabilitation Hospital of Indiana, Indianapolis, IN, USA.ORCID 0000-0002-2323-5166
Emily LucasRehabilitation Hospital of Indiana, Indianapolis, IN, USA.
Devan ParrottDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.
Christopher E HendersonDepartment of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0002-9464-2789

Funding

High-Intensity, dynamic-stability gait training in people with multiple sclerosisR01HD107145 · NICHD · MARQUETTE UNIVERSITY · PI Thomas George Hornby, BRIAN D SCHMIT · 2022 to 2026
$2.8M
Locomotor Recovery and Compensation Post-strokeR01NS118009 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI Thomas George Hornby · 2021 to 2026
$2.0M
Variable Intensive Early Walking post-Stroke (VIEWS)R01HD108622 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI Thomas George Hornby · 2023 to 2026
$1.9M
department of defenseNICHD NIH HHS R01 HD107145NICHD NIH HHS R01 HD108622NINDS NIH HHS R01 NS118009
6 · The paper itself

Abstract

BackgroundThe amount of walking practice may influence locomotor recovery in individuals with motor incomplete spinal cord injury (iSCI), although the contributions of exercise intensity are not well established.ObjectiveThe purpose of this blinded-assessor randomized trial was to determine the contributions of exercise intensity on locomotor outcomes in individuals >6 months following iSCI.MethodsAmbulatory individuals post-iSCI with walking speeds <1.0 m/s were assigned to ≤30 sessions of either high-intensity training (HIT: >70% heart rate [HR] reserve or ratings of perceived exertion [RPE] ≥15) or low-intensity training (LIT; <40% HR reserve; RPE ≤13). Assessments were performed at baseline, post-training, and at 3-month follow-up evaluation, with primary outcomes of fastest walking speeds over 10 m and during graded treadmill exercise tests, and secondary clinical and metabolic outcomes.ResultsOf 65 participants screened, 53 were randomized to HIT (n = 28) or LIT (n = 25) and completed 1489/1590 (94%) planned training sessions. Peak HRs and RPEs were greater during HIT (both

Indexed as

Exercise TherapyOutcome Assessment, Health CareSpinal Cord InjuriesWalkingAdultFemaleFollow-Up StudiesHumansMaleMiddle Agedaerobicexerciselocomotionrehabilitation

Identifiers

PMID41454653
PMCPMC12747504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.