Evidence map›Paper›PMID 41454595›Full record

ArticleCancer medicine2026

Predicting Local Recurrence in T3 Laryngeal Squamous Cell Carcinoma: An Analysis of Tumor Volume and Cartilage Invasion Prior to Radiotherapy.

Rasmus Blomkvist, Björn Palmgren, Eivind Gottlieb-Vedi, Sara Jonmarker Jaraj, Antti Mäkitie, Linda Marklund, Lalle Hammarstedt-Nordenvall

Abstract read
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In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rasmus BlomkvistDepartment of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-8581-1694
Björn PalmgrenDepartment of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Eivind Gottlieb-VediUpper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Sara Jonmarker JarajDepartment of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Antti MäkitieDepartment of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Linda MarklundDepartment of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Lalle Hammarstedt-NordenvallDepartment of Clinical Science, Intervention and Technology, CLINTEC, Otorhinolaryngology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

Funding

Finska LäkaresällskapetRadiumhemmets ForskningsfonderStiftelsen Acta Oto-Laryngologica
6 · The paper itself

Abstract

introductionPatients with T3 laryngeal squamous cell carcinoma (LSCC) face a high risk of local recurrence after chemoradiotherapy (CRT) or radiotherapy (RT). This study examines whether tumor volume and inner cortex cartilage invasion (ICCI) predict local recurrence and survival. MATERIALS AND

methodsEighty-six patients with T3 LSCC, treated with RT or CRT at the Karolinska University Hospital between 2005 and 2021, were included. Cox regression assessed the effect of associations between tumor volume and ICCI on local failure and 5-year mortality, adjusting for treatment modality, tumor subsite, and vocal cord mobility.

resultsHigh tumor volume (> 5 mL) was associated with a threefold increase in local failure risk (HR 3.11, 95% CI 1.47-6.55). No significant associations were found between tumor volume and mortality, ICCI and local failure, or ICCI and mortality.

conclusionThe results demonstrate that a larger tumor volume correlates with a reduced treatment response for patients with T3 LSCC treated with RT or CRT.

Indexed as

Laryngeal NeoplasmsNeoplasm Recurrence, LocalSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overChemoradiotherapyFemaleHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesTumor Burdenlaryngeal cancerlaryngeal squamous cell carcinomarecurrenceT3volume

Identifiers

PMID41454595
PMCPMC12743200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.