Trial reportHaemophilia : the official journal of the World Federation of Hemophilia
Low-Load Quadriceps Strengthening With Blood Flow Restriction in Adults With Haemophilic Knee Arthropathy: A Randomised Controlled Trial.
Trial report in Haemophilia : the official journal of the World Federation of Hemophilia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Low-Load Quadriceps Strengthening With Blood Flow Restriction in Adults With Haemophilic Knee Arthropathy: A Randomised Controlled Trial.Haemophilia : the official journal of the World Federation of HemophiliaTrial
- Preoperative CT-derived thigh muscle quality as a predictor of postoperative outcomes after total knee arthroplasty in patients with hemophilia.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionHaemophilic knee arthropathy leads to a reduction in muscle mass and strength. Blood flow restriction (BFR) involves the application of a compressive cuff that enables strength training with reduced loads.
objectiveTo evaluate safety as the primary outcome and the efficacy (muscle strength and activation, functional capacity and quality of life) as secondary outcomes of a quadriceps strengthening programme using BFR in patients with haemophilia.
methodsA randomised clinical trial was conducted with 33 participants assigned to either an experimental group (strength training with BFR) or a control group. The 4-week intervention included three weekly sessions and two strength exercises (leg extension and squat). Outcomes assessed were safety (clinical hemarthrosis), strength (dynamometry), muscle activation (surface electromyography), pain threshold (pressure algometry), range of motion (goniometry), functional capacity (Timed Up and Go) and quality of life (36-Item Short Form Survey). Follow-up assessments were performed 4 weeks post-intervention to evaluate effect persistence.
resultsThirty participants completed the study. No participants experienced clinical hemarthrosis or hematomas during the intervention, confirming safety as the primary outcome. Additionally, BFR training produced significant gains in quadriceps strength (p < 0.001; η
conclusionBFR strength training is safe for patients with haemophilia. It may enhance quadriceps strength and activation, raise pain thresholds and improve knee mobility. Patients show better physical functioning, less bodily pain and improved physical quality of life.
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