ArticleAngewandte Chemie (International ed. in English)2026
Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Copper-Catalyzed Amino Radical Transfer-Mediated Deborylation for Chiral Ester Synthesis.Angewandte Chemie (International ed. in English) · 2026Article
- Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.Angewandte Chemie (International ed. in English) · 2026Article
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Abstract
Multicomponent difunctionalization of 1,3-dienes has emerged as a promising strategy for rapid synthesis of valuable allylic compounds. Here, we report an unprecedented three-component 1,4-amino oxygenation of 1,3-dienes, enabled by copper catalysis and strong Brønsted acid. The reaction engages a novel mechanism that merges umpolung electrophilic amination via copper(I)-catalyzed formation of aminium radical cations and copper (II)-mediated carbon-oxygen bond formation with alcohols. The observed 1,4-selectivity is modulated by noncovalent interactions of aminated allylic intermediates. This method presents broad synthetic utility and offers a rapid entry to (E)-1,4-allylic amino ethers, which can be derivatized into various polyfunctional molecules with high stereocontrol.
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