Evidence map›Paper›PMID 41454441›Full record

ArticleCancer medicine2026

Tumor Control After Radiosurgery in Sporadic and Neurofibromatosis Type 2 Vestibular Schwannomas.

So Young Ji, Young-Hoon Kim, Won Seok Chang, Ho Kang, Jung-Il Lee, Jung Ho Han, Chae-Yong Kim, Jong Hyun Kim, Hae Won Roh, Jeong-Hyun Hwang and 22 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

So Young JiDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, South Korea.
Young-Hoon KimDepartment of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8852-6503
Won Seok ChangDepartment of Neurosurgery, Severance Hospital, Seoul, South Korea.ORCID https://orcid.org/0000-0003-3145-4016
Ho KangDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, South Korea.ORCID https://orcid.org/0000-0003-2143-410X
Jung-Il LeeDepartment of Neurosurgery, Samsung Medical Center, Seoul, South Korea.ORCID https://orcid.org/0000-0001-8143-5513
Jung Ho HanDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, South Korea.ORCID https://orcid.org/0000-0003-1748-6898
Chae-Yong KimDepartment of Neurosurgery, Seoul National University Bundang Hospital, Seongnam-si, South Korea.
Jong Hyun KimDepartment of Neurosurgery, Korea University Guro Hospital, Seoul, South Korea.
Hae Won RohDepartment of Neurosurgery, Korea University Guro Hospital, Seoul, South Korea.
Jeong-Hyun HwangDepartment of Neurosurgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea.
Seong-Hyun ParkDepartment of Neurosurgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, South Korea.
Young-Cho KohDepartment of Neurosurgery, KonKuk University Medical Center, Seoul, South Korea.
Joon ChoDepartment of Neurosurgery, KonKuk University Medical Center, Seoul, South Korea.
Seok Keun ChoiDepartment of Neurosurgery, Kyung Hee University Medical Center, Seoul, South Korea.
Chang Kyu ParkDepartment of Neurosurgery, Kyung Hee University Medical Center, Seoul, South Korea.
Se-Hyuk KimDepartment of Neurosurgery, Ajou University Medical Center, Suwon, South Korea.
Tae Hoon RohDepartment of Neurosurgery, Ajou University Medical Center, Suwon, South Korea.
Sang Ryul LeeDepartment of Neurosurgery, Ajou University Medical Center, Suwon, South Korea.
Sang-Won LeeDepartment of Neurosurgery, Pusan National University Yangsan Hospital, Pusan, South Korea.
Soon-Ki SungDepartment of Neurosurgery, Pusan National University Yangsan Hospital, Pusan, South Korea.
Moo Seong KimDepartment of Neurosurgery, Inje University Busan Paik Hospital, Pusan, South Korea.
Won Hee LeeDepartment of Neurosurgery, Inje University Busan Paik Hospital, Pusan, South Korea.
Sun-Il LeeDepartment of Neurosurgery, Inje University Haeundae Paik Hospital, Pusan, South Korea.
Seon-Hwan KimDepartment of Neurosurgery, Chungnam National University Hospital, Daejeon, South Korea.
Sae Hun KimDepartment of Neurosurgery, Chungnam National University Hospital, Daejeon, South Korea.
Kyung Hwan KimDepartment of Neurosurgery, Chungnam National University Hospital, Daejeon, South Korea.
Jung-Won ChoiDepartment of Neurosurgery, Samsung Medical Center, Seoul, South Korea.
Ho Jun SeolDepartment of Neurosurgery, Samsung Medical Center, Seoul, South Korea.
Young Hyun ChoDepartment of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Junhyung KimDepartment of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hyun Ho JungDepartment of Neurosurgery, Severance Hospital, Seoul, South Korea.
Jong Hee ChangDepartment of Neurosurgery, Severance Hospital, Seoul, South Korea.

Funding

Korean Brain and Spinal Cord Research Foundation KBSCR-022-001
6 · The paper itself

Abstract

introductionThe tumor control rate after stereotactic radiosurgery (SRS) for neurofibromatosis type 2-associated vestibular schwannomas (NF2-VSs) compared to sporadic vestibular schwannomas (S-VSs) remains unclear. This nationwide, multicenter, retrospective study (KGKRS-21-001) aimed to clarify this issue.

methodsA total of 4718 patients treated with SRS for vestibular schwannomas were analyzed from 13 nationwide institutions in Korea. NF2-VS cases were propensity score-matched with S-VS cases at a ratio of 1:1, based on age, tumor volume, and marginal dose, resulting in 122 cases in each group.

resultsNo significant differences in age, tumor volume, or marginal dose were observed between the matched cohorts. The overall tumor control rates at 1, 3, and 10 years after SRS were 93.3%, 87.7%, and 80.7%, respectively, with no significant difference between NF2-VS and S-VS groups (p = 0.63). Subgroup analysis showed that age ≤ 19 years was a significant negative prognostic factor for tumor control in NF2-VS patients (p < 0.001), whereas no such correlation was found in the S-VS cohort (p = 0.78).

conclusionsSRS provides comparable tumor control for NF2-VSs and S-VSs. However, among NF2-VS patients, younger age (≤ 19 years) was associated with poorer tumor control, suggesting that age may be a critical factor in treatment decisions.

Indexed as

Neurofibromatosis 2Neuroma, AcousticRadiosurgeryAdolescentAdultAgedFemaleHumansMaleMiddle AgedPrognosisRepublic of KoreaRetrospective StudiesTreatment OutcomeTumor BurdenYoung Adultneurofibromatosis type 2radiosurgerytumor controlvestibular schwannomaWishart phenotype

Identifiers

PMID41454441
PMCPMC12743036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.