ArticleBioelectronic medicine2025
Improved electrode stimulation stability of Utah arrays
Article in Bioelectronic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Stimulation-stability and preclinical bench testing of a new auditory nerve interface.Bioelectronic medicine · 2026Article
- Stimulation-Stability and Preclinical Bench Testing of a New Auditory Nerve Interface.Research square · 2026Article
- Neural Interfaces for Bioelectronic Medicine.Bioelectronic medicine · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe Utah electrode array (UEA) is a promising microelectrode technology with potential applications to assist patients with sensory loss, spinal cord injuries, and limb loss serving as neural prosthetics and brain-computer interfaces. Performance lifetime of microelectrodes, particularly when used for stimulation, remains one of the challenges for their clinical translation.
methodsThis study characterizes the stimulation stability of an optimized iridium oxide (IrOx) research metallization for the UEA in comparison to the Blackrock standard practice metallization. The stimulation stability (Stim-Stab) protocol used electrochemical characterization and either 106 or 4 × 106 pulses at 2,100 µA (420 nC/ph) with longitudinal voltage transient measurements and physical characterization to quantify electrode lifetime.
resultsApproximately 50% of electrodes using the Blackrock standard practice process electrical failed during 106 pulses, whereas no electrical failures were observed from 4 × 106 pulses for the research metallization. Backscattered scanning electron microscopy (BSEM) determined that all electrodes with electrical failures during Stim-Stab testing had complete loss of metallization. Of electrodes with good electrical outcomes from Stim-Stab testing 80% and 50% of those had notable metallization damage for BRM and research metallization, respectively.
conclusionsThese results suggest that the research metallization makes important steps for improving electrode metallization lifetime of Utah arrays. Additionally, the Stim-Stab method provides valuable feedback for engineering improved electrode metallization.
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Registered trials
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