ArticleEuropean journal of medical research2025
Partial meniscus allograft transplantation preserving the recipient's anterior root: a comparative study in a rabbit model.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study compared partial (PMAT) and total meniscus allograft transplantation (TMAT) in rabbits, assessing their impact on meniscus function preservation and degeneration delay. In 18 rabbits with induced meniscus defects, PMAT better preserved meniscus morphology, collagen fibers, and showed less inflammation and better cartilage protection than TMAT. Histological staining and RNA sequencing revealed PMAT maintained collagen distribution and certain gene expression patterns closer to normal tissues. These findings suggest PMAT may offer advantages in reducing inflammation, delaying degeneration, and protecting cartilage, providing a potential new clinical approach for meniscus injuries and a foundation for further exploration of meniscal repair mechanisms.
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