ArticleBMC biotechnology2025
In vitro cobalt stress alters Adhatoda vasica anatomy, antioxidant defense, and metabolite profiles with docking insights.
Article in BMC biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The growing demand for medicinal plants in herbal medicine highlights their therapeutic value, yet heavy metal contamination, such as cobalt (Co), poses potential health risks. Cobalt's dual role as an essential micronutrient and a toxic pollutant necessitates a more profound understanding of its impact on medicinal plants like Adhatoda vasica. We investigated how varying Co concentrations affect A. vasica shoot growth, leaf anatomy, antioxidant enzyme activity, and secondary metabolite profiles. Additionally, molecular docking was performed to assess the interaction of the metabolites with the skin cancer-related protein anti-ssDNA antigen-binding fragment (PDB code: 1P7K). Low Co concentrations (50 µM) enhanced shoot dry weight by 41.45%, while higher levels (100-1000 µM) reduced it by up to 66.86%. Cobalt exposure increased hydrogen peroxide (H
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