Evidence map›Paper›PMID 41454225›Full record

ArticleBMC geriatrics2025

The effect of a vegan diet with or without resistance exercise on thigh muscle volume in older adults. Research protocol of the Vold-study: a 12-week randomized controlled trial.

Jacintha Domić, Pol Grootswagers, Philippe Jm Pinckaers, Inge Groenendijk, Josep Rubert, Luc Jc van Loon, Lisette Cpgm de Groot

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05809466 (The Effect of a 12-week Self-composed Vegan Diet With or Without Concurrent Resistance Exercise on Thigh Muscle Volume in Older Adults), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05809466 nacompletednot on this map

The Effect of a 12-week Self-composed Vegan Diet With or Without Concurrent Resistance Exercise on Thigh Muscle Volume in Older Adults

TypeinterventionalSponsorWageningen UniversityRan2023 to 2024Enrolled72ConditionsVegan Diet, Sarcopenia, Cardiovascular Health, OsteoporosisArmsVegan diet, Resistance exercise, Omnivorous diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacintha DomićDivision of Human Nutrition and Health, Wageningen University & Research, P.O. Box 17, Wageningen, 6700 AA, The Netherlands. jacintha.domic@wur.nl.
Pol GrootswagersDivision of Human Nutrition and Health, Wageningen University & Research, P.O. Box 17, Wageningen, 6700 AA, The Netherlands.
Philippe Jm PinckaersDepartment of Human Biology, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre+, Maastricht, The Netherlands.
Inge GroenendijkDivision of Human Nutrition and Health, Wageningen University & Research, P.O. Box 17, Wageningen, 6700 AA, The Netherlands.
Josep RubertDivision of Human Nutrition and Health, Wageningen University & Research, P.O. Box 17, Wageningen, 6700 AA, The Netherlands.
Luc Jc van LoonDepartment of Human Biology, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre+, Maastricht, The Netherlands.
Lisette Cpgm de GrootDivision of Human Nutrition and Health, Wageningen University & Research, P.O. Box 17, Wageningen, 6700 AA, The Netherlands.

Funding

Regio Deal Foodvalley 162135
6 · The paper itself

Abstract

backgroundPlant-based diets are increasingly adopted. Plant-based foods exhibit a lower protein quantity and quality compared to animal-based foods. As such, a fully plant-based, i.e. vegan, diet may be suboptimal for the maintenance of skeletal muscle mass later in life. The primary objectives of this study protocol are therefore: (1) To assess the effect of a 12-week self-composed vegan diet in comparison to an omnivorous diet on thigh muscle volume in community-dwelling older adults; and (2) To assess the effect of a 12-week self-composed vegan diet combined with twice-weekly resistance exercise (RE) on thigh muscle volume in comparison to a vegan diet without RE in community-dwelling older adults.

methodsSeventy-two community-dwelling individuals aged ≥ 65 years with a BMI between 23 and 32 kg/m DISCUSSION: The results will provide valuable insights regarding the implications of consuming a vegan diet later in life for skeletal muscle and other health outcomes, and may contribute to the substantiation of the envisaged more plant-based dietary guidelines.

trial registrationThe trial is registered at clinicaltrials.gov (NCT05809466; registered on 22 February 2023).

Indexed as

Diet, VeganMuscle, SkeletalResistance TrainingThighAgedFemaleHumansMaleRandomized Controlled Trials as TopicAgingAnimal-based foodMuscle massPlant-based foodSkeletal muscleSustainable food

Identifiers

PMID41454225
PMCPMC12849091

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.