Evidence map›Paper›PMID 41454158›Full record

ArticleJournal of neurovirology2025

Investigation of anti-N-methyl-D-aspartate receptor and anti-myelin oligodendrocyte glycoprotein antibodies in patients with human herpesviruses-associated central nervous system infections.

Soichiro Ishimaru, Yoshiki Kawamura, Hiroshi Sakuma, Sayuri Shima, Hiroki Miura, Akihiro Ueda, Hirohisa Watanabe, Tatsuro Mutoh, Tetsushi Yoshikawa

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurovirology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Soichiro IshimaruDepartment of Pediatrics, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.
Yoshiki KawamuraDepartment of Pediatrics, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan. yoshiki@fujita-hu.ac.jp.
Hiroshi SakumaDepartment of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
Sayuri ShimaDepartment of Neurology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.
Hiroki MiuraDepartment of Pediatrics, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.
Akihiro UedaDepartment of Neurology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.
Hirohisa WatanabeDepartment of Neurology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.
Tatsuro MutohDepartment of Neurology, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake, Aichi, 470-1192, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human herpesviruses (HHVs) cause central nervous system (CNS) infections; however, the role of neural autoantibodies remains unclear. We aimed to assess the presence of anti-N-methyl-D-aspartate receptor (anti-NMDAR) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in HHV-associated CNS infections. Seventeen adults with HHV DNA in the cerebrospinal fluid were tested using flow cytometry-based assays. None of the patients tested positive for anti-NMDAR antibodies. Anti-MOG antibodies were detected in two patients with VZV-associated CNS infection, one appearing after deterioration and the other at onset. Both patients recovered without sequelae. Anti-MOG antibodies may arise in VZV-associated CNS infections, warranting the consideration of autoimmune mechanisms.

Indexed as

AutoantibodiesMyelin-Oligodendrocyte GlycoproteinReceptors, N-Methyl-D-AspartateAdultAgedDNA, ViralFemaleHerpesvirus 3, HumanHumansMaleMiddle AgedAutoantibodiesDNA, ViralMOG protein, humanMyelin-Oligodendrocyte GlycoproteinReceptors, N-Methyl-D-AspartateAntibodiesCentral nervous systemHuman herpesvirusesInfection

Identifiers

PMID41454158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.