Evidence map›Paper›PMID 41454154›Full record

ArticleScientific reports2025

Risk factors of conversion to hand-assisted laparoscopic surgery or open surgery in laparoscopic liver resection: a multicenter prospective study (HiSCO-08).

Ko Oshita, Michinori Hamaoka, Tsuyoshi Kobayashi, Takashi Onoe, Tomoyuki Abe, Toshihiko Kohashi, Koichi Oishi, Daisuke Takei, Tomoyuki Akita, Hideki Ohdan

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ko OshitaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Michinori HamaokaDepartment of Gastroenterological, Breast and Transplant Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan. oosaji5hai@gmail.com.
Tsuyoshi KobayashiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Takashi OnoeDepartment of Gastroenterological Surgery, Chugoku Cancer Center, Kure Medical Center, National Hospital Organization, Hiroshima, Japan.
Tomoyuki AbeDepartmet of Gastroenterological Surgery, Higashihiroshima Medical Center, National Hospital Organization, Hiroshima, Japan.
Toshihiko KohashiDepartment of Hepato-Biliary-Pancreatic Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Koichi OishiDepartment of Surgery, Chugoku Rosai Hospital, Hiroshima, Japan.
Daisuke TakeiDepartment of Surgery, Onomichi General Hospital, Hiroshima, Japan.
Tomoyuki AkitaDepartment of Epidemiology, Graduate School of Biomedical and Health Sciences, Infectious Disease Control and Prevention, Hiroshima University, Hiroshima, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Funding

Japan Agency for Medical Research and Development,Japan JP24fk0210108
6 · The paper itself

Abstract

Laparoscopic liver resection (LLR) is widely accepted; however, no prospective study has identified risk factors for conversion to open surgery. This multicenter prospective study aimed to identify risk factors for conversion to hand-assisted laparoscopic surgery or open liver resection and evaluate the impact of conversion on perioperative outcomes in LLR. From June 2020 to May 2024, patients scheduled for wedge resection or left lateral segmentectomy for solitary liver tumor < 5 cm were enrolled across seven institutions. A laparoscopic approach was employed for all patients. The primary endpoint was the identification of risk factors for conversion. As secondary endpoints, we compared perioperative outcomes between LLR and conversion. Among 199 patients, 172 (86.4%) completed LLR, while 27 (13.6%) required conversion. Multivariate analysis identified third or subsequent liver resection (P < 0.001) and male sex (P = 0.029) as significant risk factors for conversion. Conversion was significantly associated with longer operative time (P = 0.001), greater blood loss (P < 0.001), decreased implementation of the Pringle maneuver (P = 0.013), and prolonged hospital stay (P = 0.001). These findings highlight that conversion negatively impacts short-term outcomes. Awareness of these risk factors may support better surgical planning and risk stratification for patients undergoing LLR.

Indexed as

Conversion to Open SurgeryHand-Assisted LaparoscopyHepatectomyLaparoscopyLiver NeoplasmsAdultAgedFemaleHumansLength of StayMaleMiddle AgedOperative TimeProspective StudiesRisk FactorsTreatment OutcomeConversionHand-assisted laparoscopic surgeryLaparoscopic liver resectionOpen liver resectionRepeat liver resection

Identifiers

PMID41454154
PMCPMC12852719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.