Evidence map›Paper›PMID 41454089›Full record

ArticleBlood research2025

STING-Dependent spontaneous platelet adhesion potentiates NK cell proinflammatory responses in pediatric crohn's disease.

Jiajia Lv, Meng Zhang, Xinqiong Wang, Xu Xu, Jia Li, Junqi Wang, Chundi Xu, Yi Yu, Wei Cao, Yuan Xiao

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Article in Blood research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiajia Lv *Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Meng Zhang *Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Xinqiong WangDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Xu XuDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Jia LiDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Junqi WangDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Chundi XuDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Yi YuDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China.
Wei CaoDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China. cw11889@rjh.com.cn.
Yuan XiaoDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Er Road, Shanghai, 200025, China. xy11438@rjh.com.cn.

Funding

Clinical Research Center for Pediatric Inflammatory Bowel Disease of Shanghai Jiao Tong University School of Medicine ELYZX202203National Natural Science Foundation of China 81900015
6 · The paper itself

Abstract

backgroundPlatelets are hypothesized to participate in the pathogenesis of Crohn's disease (CD) by interacting with other inflammatory cells such as natural killer (NK) cells. In this study, we aimed to evaluate the effects of platelet-NK cell interactions, both in vitro and in vivo, along with the corresponding mechanisms.

methodsClinical data were collected from patients with CD and IL-10 receptor alpha (IL-10RA) mutations, with the control group being comprised of patients with functional abdominal pain. Platelets and NK cells from the patients' colon tissues were immunostained. Dextran sulfate sodium (DSS)-induced colitis models using wild type (WT) and Stimulator of Interferon Genes knockout (STING

resultsCirculating and intestinal platelets were higher in patients with IL-10RA mutations compared to CD patients and correlated positively with serum cytokines, fecal calprotectin (FCP), and blood NK cells. Gut inflammation and T3 cytokine expression in NK cells were significantly lower in STING

conclusionsSpontaneous platelet adhesion via STING signaling potentiates NK cell proinflammatory response in CD.

Indexed as

CD24Crohn’s diseaseCytokineInterleukin 10 receptor mutationNK cellsPlatelets

Identifiers

PMID41454089
PMCPMC12852555

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