ArticleFrontiers of medicine2025
LMWH prophylaxis in pregnancy outcomes of women with suspected protein S deficiency: a retrospective case-control study.
Article in Frontiers of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations Between Peripheral Blood Inflammatory and Immune Markers and Osteoporotic and Fragility Fractures: A Systematic Review and Meta-Analysis.Calcified tissue international · 2026Pooled it
- Short-term light sedation with remimazolam besylate versus propofol in the ICU (SHOSREB): a multicentre, randomized, single-blind, controlled trial.Intensive care medicine · 2026Trial
- Comment on "MRI and PET-Based Machine Learning Radiomics for Metastasis Prediction in Pancreatic Ductal Adenocarcinoma: A Systematic Review".Journal of gastrointestinal cancer · 2026Article
- Piperazine derivatives as anticancer agents: a medicinal chemistry review of structure, mechanism, and clinical translation.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Therapeutic role of low molecular weight heparin and fat-soluble vitamins in pregnancy-associated prethrombotic conditions.Frontiers in medicine · 2026Review
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27 authors.
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Abstract
Given the maternal hypercoagulability during pregnancy, thrombophilia may increase the risk of adverse pregnancy outcomes (APOs). This retrospective case-control study aimed to assess whether low-molecular-weight heparin (LMWH) could improve APOs in women with protein S (PS) deficiency. We selected 35 pregnant women who were considered for potential PS deficiency, and 70 healthy pregnant women were randomly selected as the control group. Two or more consecutive miscarriages were more frequent in pregnant women with PS deficiency than in the control group (12/35 vs. 4/70, P = 0.0001). Ten pregnant women with PS deficiency conceived by in vitro fertilization-embryo transfer (IVF-ET), which was significantly higher than the number of controls who conceived by IVF-ET (4/70, P = 0.0012). All 20 women in the LMWH-treated group (P = 0.001) had live births, which were significantly higher than that in the LMWH-untreated group (8/15, 53.3%). In the subgroup aged ⩽ 32 years of age, the number of live births in both groups was 7 (7/7, 100%) and 7 (7/12, 58.3%), respectively (P = 0.106). In conclusion, impediments to spontaneous conception and an elevated incidence of pregnancy loss may be associated with PS deficiency. Furthermore, the elevated live birth rate might be attributable to the administration of LMWH during gestation.
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