Observational studyLangenbeck's archives of surgery2025
Intraoperative peak lactate as a predictor of in-hospital mortality following non-cardiac emergency surgery: a retrospective cohort study.
Observational study in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe association between intraoperative lactate levels and postoperative prognosis following emergency surgery remains inconclusive. We aimed to investigate the prognostic significance of intraoperative lactate levels in predicting in-hospital mortality.
methodsThis single-center, retrospective, observational study was conducted at Peking Union Medical College Hospital from 2017 to 2023. Intraoperative peak lactate levels were analyzed using a restricted cubic spline (RCS) model, with in-hospital mortality designated as the primary outcome. Secondary outcomes were length of stay, ICU stay, and ventilation duration. Prespecified subgroup analyses (by ASA grade and surgery type) and a sensitivity analysis excluding in-hospital deaths for secondary endpoints were performed.
resultsAmong the 2,452 patients included in the study, 161 died postoperatively. Both univariate and multivariate regression analyses demonstrated that the intraoperative peak lactate level was associated with perioperative mortality (odds ratio [OR] 1.306, 95% CI 1.262-1.352, P < 0.001; OR 1.249, 95% CI 1.185-1.318, P < 0.001). The association was consistent across surgery types and appeared stronger in patients with higher ASA grade. The restricted cubic spline model indicated higher intraoperative peak lactate levels were nonlinearly associated with increased in-hospital mortality. Length of hospital stay (LOS), LOS in the intensive care unit (ICU), and duration of mechanical ventilation exhibited a nonlinear (inverted U-shaped) pattern relationship with intraoperative peak lactate levels, with an initial increasing trend followed by a subsequent decline as peak lactate concentrations rose.
conclusionsIntraoperative peak lactate levels showed a dose-dependent nonlinear association with increased in-hospital mortality following emergency surgery and play a significant role in predicting postoperative mortality in noncardiac emergency surgery patients.
trial registrationNot applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.