Evidence map›Paper›PMID 41453985›Full record

ArticleScientific reports2025

Evaluation of the effect of resveratrol on bone healing after tooth extraction in rats treated with zoledronic acid.

Ayse Ozcan Kucuk, Burak Ak, Sakir Necat Yilmaz, Deniz Kibar, Ayse Betul Guk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ayse Ozcan KucukDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mersin University, Çiftlikköy Campus, 33343, Yenişehir/Mersin, Türkiye. ayseozcan89@hotmail.com.ORCID http://orcid.org/0000-0002-8289-8066
Burak AkDepartment of Periodontology. Faculty of Dentistry, Mersin University, 33343, Mersin, Türkiye.ORCID http://orcid.org/0000-0001-5013-6588
Sakir Necat YilmazDepartment of Histology and Embryology, Faculty of Medicine, Mersin University, 33343, Mersin, Türkiye.ORCID http://orcid.org/0000-0003-1759-3052
Deniz KibarDepartment of Biology, Faculty of Science, Mersin University, 33343, Mersin, Türkiye.ORCID http://orcid.org/0000-0001-7114-6021
Ayse Betul GukDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mersin University, 33343, Mersin, Türkiye.ORCID http://orcid.org/0009-0001-3741-582X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the potential use of resveratrol on bone healing after tooth extraction in zoledronic acid-treated rats. Seventy-two Wistar rats were separated into 4 groups of 18: no drugs (control group), zoledronic acid (ZA), resveratrol (RES), zoledronic acid + resveratrol (ZA + RES). The first and second molars of each rat were extracted and nine rats from each group were sacrificed on days 14 and 28. The extraction sites and blood samples were analyzed histologically, immunohistochemically and biochemically. The epithelization, connective tissue, new bone formation in RES group was significantly higher compared to ZA and ZA + RES groups on day 28. The connective tissue in control group was significantly higher compared to ZA and ZA + RES groups on days 14 and 28. BMP-4 levels in RES group were significantly higher compared to the other groups on days 14 and 28. Serum CTX levels in ZA + RES group were significantly higher compared to control and RES groups on day 14. Serum TRACP-5b levels in ZA + RES group, were significantly higher compared to control and RES groups on day 14. TRACP-5b level of the control was significantly lower than ZA and ZA + RES groups. Although resveratrol improved new bone formation in normal rats, no significant positive effects were detected in zoledronic acid-injected rats.

Indexed as

Bone Density Conservation AgentsResveratrolTooth ExtractionWound HealingZoledronic AcidAnimalsDiphosphonatesImidazolesMaleMolarOsteogenesisRatsRats, WistarBone Density Conservation AgentsDiphosphonatesImidazolesResveratrolZoledronic AcidAntioxidantBisphosphonateMRONJOsteonecrosisResveratrolTooth extraction

Identifiers

PMID41453985
PMCPMC12852866

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.