Evidence map›Paper›PMID 41453978›Full record

ArticleNPJ Parkinson's disease2025

MRI-derived atrophy in multiple system atrophy aligns with mitochondrial and glial gene expression patterns.

Lydia Chougar, Christina Tremblay, Aline Delva, Marie Filiatrault, Andrew Vo, Justine Y Hansen, Asa Farahani, Bratislav Misic, Parsa Khalafi, Charles-Etienne Castonguay and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lydia ChougarThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. chougar.lydia@gmail.com.
Christina TremblayCenter for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
Aline DelvaThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Marie FiliatraultCenter for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada.
Andrew VoThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Justine Y HansenThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Asa FarahaniThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Bratislav MisicThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Parsa KhalafiThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Charles-Etienne CastonguayThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Guy RouleauThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Jean-Christophe CorvolSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, AP-HP, CNRS, Inserm, Hôpital de la Pitié Salpêtrière, Department of Neurology, Paris, France.
Marie VidailhetSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, AP-HP, CNRS, Inserm, Hôpital de la Pitié Salpêtrière, Department of Neurology, Paris, France.
Bertrand DegosDynamics and Pathophysiology of Neuronal Networks Team, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, UMR7241/INSERM U1050, Université PSL, Paris, France.
Nadya PyatigorskayaSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, AP-HP, CNRS, Inserm, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, Paris, France.
Christine PayanDépartement de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, APHP, UPMC Pharmacologie, Paris 6, Paris, France.
David GrabliSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, AP-HP, CNRS, Inserm, Hôpital de la Pitié Salpêtrière, Department of Neurology, Paris, France.
Stéphane LehéricySorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, AP-HP, CNRS, Inserm, Hôpital de la Pitié Salpêtrière, DMU DIAMENT, Department of Neuroradiology, Paris, France.
Alain DagherThe Neuro - Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Shady RahayelCenter for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada. shady.rahayel@umontreal.ca.

Funding

Agence Nationale de la Recherche ANR-10-IAIHU-06Programme Hospitalier de Recherche Clinique PHRC 2007-A00169-44, PHRC 2004 (BBBIPPS)
6 · The paper itself

Abstract

Oligodendroglial pathology is a hallmark of multiple system atrophy (MSA), yet it remains unclear whether MRI-detected atrophy reflects underlying biological mechanisms. This study investigated whether regional atrophy aligns with gene expression and neurotransmitter systems. We recruited 65 MSA patients and derived brain atrophy measures from T1-weighted MRIs. Using postmortem data from the Allen Human Brain Atlas, partial least squares (PLS) regression identified gene expression components associated with brain atrophy. Gene enrichment analyses explored biological processes, and annotation mapping identified neurotransmitter systems matching atrophy patterns. Specificity was tested against 57 patients with Parkinson's disease. Atrophy primarily affected the cerebellar white matter, pons, putamen, olive, and substantia nigra. PLS revealed two latent variables explaining 27.5% of the covariance. Atrophic regions overexpressed genes linked to mitochondrial function and oligodendrocytes, showing patterns distinct from Parkinson's disease. These regions also exhibited lower serotonin and GABA levels, and higher acetylcholine and noradrenaline receptor densities. MRI-derived atrophy in MSA is biologically grounded and may inform future therapeutic studies.

Identifiers

PMID41453978
PMCPMC12800306

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.