Evidence map›Paper›PMID 41453945›Full record

ArticleCell death & disease2025

Non-canonical NOTCH1 signaling regulates ferroptosis vulnerability in dormant lung cancer cells with stable resistance.

Hongli Huang, Yihan Chai, Xuewei Wu, Sen Wang, Binglin Li, Yanyan Wang, Wen Zheng, Yuefeng Wu, Di Meng, Hua Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hongli HuangKey Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.ORCID http://orcid.org/0000-0002-6586-3857
Yihan ChaiZhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China.
Xuewei WuZhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China.ORCID http://orcid.org/0000-0003-1047-0041
Sen WangZhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China.ORCID http://orcid.org/0009-0005-5364-7179
Binglin LiZhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China.ORCID http://orcid.org/0009-0007-6219-9376
Yanyan WangZhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China.
Wen ZhengZhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China.ORCID http://orcid.org/0009-0008-2718-1549
Yuefeng WuWestlake Laboratory of Life Sciences and Biomedicine, School of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0001-9351-1720
Di MengDepartment of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hua WangInternational Business School, Zhejiang University, Jiaxing, China.ORCID http://orcid.org/0000-0001-5186-4165
Zhengliang TuDepartment of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-1990-7265
Chengli DuDepartment of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-5753-6234
Xiayi Lyu *Department of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. lyuxiayi@zju.edu.cn.
Guiying Li *Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. ligy@jlu.edu.cn.ORCID http://orcid.org/0000-0002-7910-5387
Wei Guo *Zhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, China. weiguo@intl.zju.edu.cn.ORCID http://orcid.org/0000-0002-2226-2613

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81974455National Natural Science Foundation of China (National Science Foundation of China) 8217110405National Natural Science Foundation of China (National Science Foundation of China) 82173351Science and Technology Department of Zhejiang Province 2025C02095
6 · The paper itself

Abstract

Non-genetic resistance of cancer remains poorly understood in clinical research and practice. To better understand resistant cancer cell heterogeneity, we isolated a novel riboflavin

Indexed as

Drug Resistance, NeoplasmFerroptosisLung NeoplasmsReceptor, Notch1Signal TransductionAnimalsCell Line, TumorCisplatinEpithelial-Mesenchymal TransitionHumansMiceNeoplastic Stem CellsReactive Oxygen SpeciesCisplatinNOTCH1 protein, humanReactive Oxygen SpeciesReceptor, Notch1

Identifiers

PMID41453945
PMCPMC12780219

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.