Evidence map›Paper›PMID 41453943›Full record

ArticleNature communications2025

Backpropagation through space, time and the brain.

Benjamin Ellenberger, Paul Haider, Federico Benitez, Jakob Jordan, Kevin Max, Ismael Jaras, Laura Kriener, Mihai A Petrovici

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Neuromorphic Devices and Computing for Sensing, Memory, and Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Self-Contrastive Forward-Forward algorithm.Nature communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin Ellenberger *Department of Physiology, University of Bern, Bern, Switzerland.
Paul Haider *Department of Physiology, University of Bern, Bern, Switzerland. paul.haider@unibe.ch.ORCID http://orcid.org/0000-0002-4254-5143
Federico BenitezDepartment of Physiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-7978-970X
Jakob JordanDepartment of Physiology, University of Bern, Bern, Switzerland.
Kevin MaxDepartment of Physiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-9433-2190
Ismael JarasDepartment of Physiology, University of Bern, Bern, Switzerland.
Laura KrienerDepartment of Physiology, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-5275-9199
Mihai A PetroviciDepartment of Physiology, University of Bern, Bern, Switzerland. mihai.petrovici@unibe.ch.ORCID http://orcid.org/0000-0003-2632-0427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How physical neuronal networks, bound by spatio-temporal locality constraints, can perform efficient credit assignment, remains an intriguing question. Both backward- and forward-propagation algorithms rely on assumptions that violate this locality in various ways. We introduce Generalized Latent Equilibrium (GLE), a framework for fully local spatio-temporal credit assignment in physical, dynamical neuronal networks. From an energy based on neuron-local mismatches, we derive neuronal dynamics via stationarity and parameter dynamics as gradient descent. The result is an online approximation of backpropagation through space and time in deep networks of cortical microcircuits with continuously active, local synaptic plasticity. GLE exploits dendritic morphology to enable complex information storage and processing in single neurons, as well as their ability to react in anticipation of their future input. This "prospective coding" enables the computation of spatio-temporal convolutions in the forward direction and the approximation of adjoint variables in the backward stream.

Indexed as

BrainModels, NeurologicalNerve NetNeuronsAlgorithmsAnimalsHumansNeural Networks, ComputerNeuronal Plasticity

Identifiers

PMID41453943
PMCPMC12770517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.