ArticleScientific reports2025
Catechin hydrate induces GFAP expression and astrocyte branch elongation in rat neural stem cells.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Neural stem cells (NSCs) are multipotent cells capable of self-renewal and differentiate into diverse cell types within the central nervous system, including neurons, astrocytes, and oligodendrocytes. Catechin hydrate (CH) belongs to the flavonoid family and can be found in green tea and grape seeds. In the present study, we have explored the effect of CH on NSC fate at the molecular level. CH increased both mRNA and protein expression of glial fibrillary acidic protein during NSC differentiation. However, the number of astrocytes was not significantly altered. CH enhanced leukemia inhibitory factor, and bone morphogenetic protein mRNA levels and increased phosphorylation of STAT3 and SMAD1/5/8 in differentiated cells. CH increased fibroblastic growth factor 2 mRNA levels and induced the formation of thin and elongated branches in differentiating astrocytes. These results suggest that although CH does not increase astrocytogenesis, it contributes to regulating astrocytes to become longer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.