Evidence map›Paper›PMID 41453864›Full record

ArticleCell death discovery2025

The fungal peptide toxin candidalysin induces distinct membrane repair mechanisms compared to bacterial pore-forming toxins.

Roshan Thapa, Victor Kayejo, Claire M Lyon, Bernhard Hube, Julian R Naglik, Peter A Keyel

Abstract read
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Phenotypic and genotypic analysis ofInfection and immunity · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Roshan ThapaDepartment of Biological Sciences, Texas Tech University, Lubbock, TX, USA.ORCID http://orcid.org/0000-0002-0705-906X
Victor KayejoDepartment of Biological Sciences, Texas Tech University, Lubbock, TX, USA.ORCID http://orcid.org/0000-0002-9947-1931
Claire M LyonCentre for Host-Microbiome Interactions, Faculty of Dental, Oral & Craniofacial Sciences, King's College London, London, UK.
Bernhard HubeDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute (HKI), Jena, Germany.
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dental, Oral & Craniofacial Sciences, King's College London, London, UK.
Peter A KeyelDepartment of Biological Sciences, Texas Tech University, Lubbock, TX, USA. peter.keyel@ttu.edu.ORCID http://orcid.org/0000-0001-8637-8538

Funding

Novel membrane defense systems utilized by the human pathogen LeishmaniaR21AI156225 · NIAID · TEXAS TECH UNIVERSITY · PI KEYEL, PETER A · 2021 to 2022
$405k
American Heart Association (American Heart Association, Inc.) 16SDG30200001American Heart Association (American Heart Association, Inc.) https://doi.org/10.58275/AHA.23IPA1053083.pc.gr.171946American Heart Association-American Stroke Association 16SDG30200001American Heart Association-American Stroke Association 23IPA1053083NIAID NIH HHS R21 AI156225U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1R21AI156225Wellcome TrustWellcome Trust (Wellcome) 214229_Z_18_Z
6 · The paper itself

Abstract

The common fungal pathogen, Candida albicans, relies on the pore-forming toxin candidalysin to damage host cells. Cells counteract pore-forming toxins by Ca

Identifiers

PMID41453864
PMCPMC12847973

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.