Evidence map›Paper›PMID 41453852›Full record

ArticleCell death & disease2025

YTHDF3 suppresses interferon-stimulated gene (ISG)-dependent antitumor immunity and promotes HPV carcinogenesis in cervical cancer.

Li Li, Dongmei Lin, Keyi Ao, Sheng Zhong, Hui He, Xin Li, Yi Hao, Xia Guo

Abstract read
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li Li *Shenzhen Key Laboratory of Viral Oncology; Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China.
Dongmei Lin *Department of Medical Ultrasonics, South China Hospital, Medical School, Shenzhen University, Shenzhen, PR China.
Keyi AoShenzhen Key Laboratory of Viral Oncology; Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China.
Sheng ZhongShenzhen Key Laboratory of Viral Oncology; Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China.
Hui HeDepartment of Pathology, Shenzhen Hospital, The University of Hong Kong, Shenzhen, PR China.
Xin LiShenzhen Key Laboratory of Viral Oncology; Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China. xinli268@gmail.com.ORCID http://orcid.org/0000-0003-0958-1078
Yi HaoDepartment of Medical Ultrasonics, South China Hospital, Medical School, Shenzhen University, Shenzhen, PR China. haoyi0320sz@163.com.ORCID http://orcid.org/0000-0002-0248-8279
Xia GuoShenzhen Key Laboratory of Viral Oncology; Department of Science and Innovation, Shenzhen Hospital, Southern Medical University, Shenzhen, PR China. myshow0504@smu.edu.cn.ORCID http://orcid.org/0000-0002-6022-9128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interferon-stimulated genes (ISGs) serve as evolutionarily conserved mediators of antiviral defense and tumor surveillance. Emerging evidence underscores the non-oncogenic addiction of high-risk human papillomavirus (hrHPV) E6/E7 oncoproteins in maintaining malignant phenotypes and cervical carcinogenesis. Here, we leveraged CRISPR/Cas9-engineered YTHDF3-knockout (YTHDF3

Indexed as

CarcinogenesisPapillomavirus InfectionsRNA-Binding ProteinsUterine Cervical NeoplasmsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMiceMice, KnockoutTumor MicroenvironmentRNA-Binding ProteinsYTHDF3 protein, human

Identifiers

PMID41453852
PMCPMC12827990

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.