Evidence map›Paper›PMID 41453699›Full record

ArticleArchives of biochemistry and biophysics2026

Staphylococcus aureus sensor histidine kinase VraS mutations linked to antibiotic resistance affect enzymatic catalysis, stability, and substrate interactions.

Brittnee Cagle-White, Shrijan Bhattarai, Allison Sunderhaus, Emerald Scott, Araceli Solis, Lane Marsh, Kristina L Catague, Aurijit Sarkar, May H Abdel Aziz

Abstract read
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In one paragraph

Article in Archives of biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brittnee Cagle-WhiteFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Shrijan BhattaraiFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Allison SunderhausFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Emerald ScottFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Araceli SolisFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Lane MarshFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Kristina L CatagueFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA.
Aurijit SarkarDepartment of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE, USA.
May H Abdel AzizFisch College of Pharmacy, The University of Texas at Tyler, Tyler, TX, USA. Electronic address: mabdelaziz@uttyler.edu.

Funding

Mechanistic Insights into VraS Mutations Linked to Bacterial ResistanceR21AI154189 · NIAID · UNIVERSITY OF TEXAS TYLER · PI ABDELAZIZ, MAY H. · 2021 to 2022
$381k
NIAID NIH HHS R21 AI154189
6 · The paper itself

Abstract

Staphylococcus aureus (S. aureus) is a highly pathogenic bacterium that utilizes the VraSR two-component system to regulate cell wall synthesis and facilitate resistance against antibiotics. Resistant S. aureus isolates were shown to harbor several single-nucleotide polymorphisms in VraS; however, their effect on VraS functionality is not clear. We have investigated the effect of seven mutations in the VraS intracellular domain reported in clinically resistant strains on autophosphorylation rate, stability, and VraS-VraR equilibrium binding affinity (K

Indexed as

Bacterial ProteinsDrug Resistance, BacterialHistidine KinaseProtein KinasesStaphylococcus aureusAnti-Bacterial AgentsEnzyme StabilityKineticsMutationPhosphorylationSubstrate SpecificityAnti-Bacterial AgentsBacterial ProteinsHistidine KinaseProtein KinasesVraS protein, Staphylococcus aureusCatalysisEnzyme mutationHistidine kinaseprotein‐protein interactionStaphylococcus aureus

Identifiers

PMID41453699
PMCPMC13138610

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.