ArticleInternational dental journal2026
METTL3-Mediated m6A Modification of DSC1 Alleviates Inflammation and Cellular Dysfunction in Periodontitis.
Article in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- METTL3 Regulates the Senescence of Stem Cells From the Apical Papilla by Mediating the mInternational dental journal · 2026Article
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2 authors.
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Abstract
backgroundThe inflammation and cellular dysfunction in periodontitis largely depend on N6-methyladenosine (m
methodsPeriodontal ligament (PDL) tissues were collected from patients with periodontitis and healthy volunteers, and a periodontitis model was constructed using lipopolysaccharide (LPS) and human periodontal ligament fibroblasts (HPLF). METTL3 and DSC1 levels in the specimens and cells were measured using quantitative reverse-transcription polymerase chain reaction. Proliferation, apoptosis, and inflammatory changes were analyzed using CCK-8, EdU, flow cytometry, and enzyme-linked immunosorbent assay, respectively. Additionally, m
resultsThe expression levels of METTL3 and DSC1 were lower in patients with periodontitis compared to those in the healthy group. LPS treatment inhibited the survival of HPLF cells, promoting apoptosis and inflammation; alternatively, DSC1 overexpression alleviated the LPS-induced damage to periodontitis cells. Furthermore, METTL3 positively regulated the DSC1 level and enhanced its stability through m
conclusionThese findings suggest that METTL3 mediates the m
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